• New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children 

  Okuyan, Ömer; Elgörmüş, Yusuf; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize (MDPI, 2023)

  Aim: This study evaluated the relationship between the systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) with clinical findings of respiratory syncytial ...

• In vitro effects of heparin-binding epidermal growth factor on adhesion stage of implantation 

  Biltekin, Burcu; Bilir, Ayhan; Seçkin, İsmail; Şentürk, Gözde Erkanlı (EDITURA ACAD ROMANE, 2023)

  A member of the epidermal growth factor (EGF) family, the heparin-binding EGF (HB-EGF) is expressed in the uteri of both humans and mice during the implantation process. To study the effects of HB-EGF on adhesion stage, ...

• The Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes 

  Fenercioglu, Aysen Kutan; Gonen, Mustafa Sait; Uzun, Hafize; Sipahioglu, Nurver Turfaner; Can, Gunay; Tas, Ebru; Kara, Zehra (Mdpi, 2023)

  In this study, we aimed to reveal the pro-inflammatory effects of serum 25-hydroxyvitamin D3 (Vit D) deficiency and insufficiency in new-onset type 2 diabetes mellitus (T2DM) and prediabetes. We recruited 84 prediabetes ...

• Prediction of Preterm Delivery Using Serum Ischemia Modified Albumin, Biglycan, and Decorin Levels in Women with Threatened Preterm Labor 

  Bıyık, İsmail; Soysal, Cenk; İnce, Özlem Ulaş Onur; Durmuş, Sinem; Öztaş, Efser; Keskin, Nadi; Işıklar, Özben Özden; Karaağaç, Oğuz Han; Gelişgen, Remise; Uzun, Hafize (Georg Thieme Verlag KG, 2023)

  Objective The serum ischemia modified albumin (IMA), biglycan, and decorin levels of pregnant women who were hospitalized for threatened preterm labor were measured.Methods Fifty-one consecutive pregnant women with a single ...

• The Role of Glycogen Synthase Kinase-3β in the Zinc-Mediated Neuroprotective Effect of Metformin in Rats with Glutamate Neurotoxicity 

  Oruc, Aykut; Oruc, Kadriye Yagmur; Yanar, Karolin; Mengi, Murat; Caglar, Aysel; Kurt, Bahar Öztürk; Altan, Mehmet; Sönmez, Osman Fuat; Cakatay, Ufuk; Uzun, Hafize; Simsek, Gönül (Wiley, 2023)

  Metformin has been suggested to have protective effects on the central nervous system, but the mechanism is unknown. The similarity between the effects of metformin and the inhibition of glycogen synthase kinase (GSK)-3β ...

• Neutralization of Wild-Type and Alpha SARS-CoV-2 Variant by CoronaVac® Vaccine and Natural Infection- Induced Antibodies 

  Özkaya, Esra; Yazıcı, Merve; Baran, Irmak; Çetin, Nesibe Selma; Tosun, İlknur; Buruk, Celal Kurtuluş; Kaklikkaya, Neşe; Aydın, Faruk; Doymaz, Mehmet Ziya (Springer, 2023)

  One of the immune responses desired to be achieved by SARS-CoV-2 vaccination is to create neutralizing antibodies (nAbs), thus preventing the development and spread of infection. The aim of this study was to investigate ...

• The Role of NF-κB, PPAR-α, and PPAR-γ in Older Adults with Metabolic Syndrome 

  Demirağ, Filiz; Yavuzer, Serap; Cengiz, Mahir; Yavuzer, Hakan; Kara, Zehra; Ayvacı, Adnan; Avcı, Suna; Yürüyen, Mehmet; Uzun, Hafize; Altıparmak, Mehmet Rıza (Georg Thieme Verlag KG, 2023)

  The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood yet, and chronic low-grade inflammation is thought to be associated with the development of complications related to MetS. We aimed to investigate ...

• Evaluation of Cytotoxicity and Antibacterial Effect of Different Types of Mineral Trioxide Aggregate 

  Ünlü, Özge; Egil, Edibe; Demirci, Mehmet; Kuşoğlu, Seda (Galenos Publishing House, 2023)

  Objective: Mineral trioxide aggregate (MTA) has been used as a filling material in endodontic procedures over decades. The newer formulations of MTA were launched in the dental market and their cytotoxic, proliferative and ...

• Activation of TRESK Channels Ameliorates Pain and Neurogenic Inflammation in a Nitroglycerin-Induced Migraine Model in Rats 

  Torun, İbrahim Ethem; Kilinc, Yasemin Bakanoğlu; Kilinc, Erkan; Töre, Fatma (Wiley, 2023)

  We investigated effects of activation of TRESK channels by selective activator cloxyquin on excitotoxic-induced brain injury and neuroinflammation involving brain mast cells and inflammatory cytokines in neonatal rats. ...

• Oral Microbiota Signatures in the Pathogenesis of Euthyroid Hashimoto's Thyroiditis 

  Erdem, Mustafa Genco; Ünlü, Özge; Ateş, Fatma; Karis, Denizhan; Demirci, Mehmet (MDPI, 2023)

  One of the most prevalent autoimmune illnesses in the world is Hashimoto's thyroiditis, whose pathogenesis is still unknown. The gut-thyroid axis is frequently examined, and although oral health affects thyroid functions, ...

• Synthesis and Anticancerogenic Effect of New Generation Ruthenium-Based Nanoparticle from Homalothecium sericeum with Eco-Friendly Method 

  Samir, Nourhan; Ozerkan, Dilsad; Danisman-Kalindemirtas, Ferdane; Kariper, Ishak Afsin; Bulut, Huri; Kuruca, Düerdane Serap; Altuner, Ergin Murat; Ulukaya, Engin (Springer, 2023)

  BackgroundGreen synthesis is a simple, inexpensive, and highly efficient method for the preparation of nanoparticles. In this study, ethanol extracts of Homalothecium sericeum (HOM) moss were used as reducing agents for ...

• A Longitudinal Study in Turkiye of Host Ability to Produce Antibodies following a Third Homologous BNT162b2 Vaccination 

  Erdem, Mustafa Genco; Ünlü, Özge; Demirci, Mehmet (MDPI, 2023)

  Obesity is a multifaceted, complex condition that has negative impacts on one's health. There are conflicting reports regarding the COVID-19 vaccine's ability to induce antibody formation in obese people. Our study aimed ...

• Alpha-lipoic acid could be a promising treatment in steroid-induced osteonecrosis 

  Koca, İrfan; Uçar, Mehmet; Arık, H. O.; Yılmaz, Mehmet; Dokuyucu, Recep (Verduci International, 2022)

  OBJECTIVE: Glucocorticoid-induced osteonecrosis is a serious debilitating health problem. In the present study, we investigated the effects of alpha-lipoic acid on glucocorticoid-induced osteonecrosis in rats. MATERIALS ...

• The role of laparoscopic sleeve gastrectomy on inflammatory parameters n morbidly obese patients 

  Ergun, S.; Ergun, D. D.; Akıncı, O.; Taşkın, Halit Eren; Simsek, Gönül; Taşkın, M.; Uzun, Hafize (Elsevier Masson, Corp Off, 2022)

  Background: Obesity is an excessive increase in body fat mass and triggers chronic inflammation which causes increased fat accumulation in the visceral fat tissue. The aim of this study was to analyze serum zinc (Zn), ...

• Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy 

  Doğan, Zeki; Ergun, D. D.; Durmus, S.; Şahin, Hilal; Şentürk, G. E.; Gelişgen, Remise; Senyigit, A.; Uzun, Hafize (Verduci Publisher, 2023)

  Objective: Oxidative stress and hypoxia play an important role in the pathogenesis of various cardiovascular diseases. We aimed to evaluate the effectiveness of sacubitril/valsartan (S/V) and Empagliflozin (EMPA) on ...

• Maternal serum preptin levels in the pathogenesis and diagnosis of gestational diabetes mellitus 

  Kıraç Utku, İrem; Demir, Esra; Özkan, Hanişe; Sahtiyancı, Berrak; Uzun, Hafize; Ekinci, İskender; Büyükkaba, Mitat; Durmuş, Sinem; Akarsu, Murat; Gelişgen, Remise; Tabak, Ömür (Society of Medical Biochemists of Serbia, 2023)

  Background: Gestational diabetes mellitus (GDM) is a metabolic disorder that occurs during pregnancy that increases both maternal and fetal mortality and morbidity. It was investigated whether there is a change in circulating ...

• The Effects of Darbepoetin Alfa on the Changes Induced by Ethanol in Glucose Metabolism and Lipid Profile 

  Uygur, Emine; Seymen, Hakkı Oktay; Uzun, Hafize; Tunçdemir, Matem; Öz, Aysim Buğe; Polat, Elif; Yılmaz, Ahsen; Yaman, Elif (Wiley, 2023)

• Neuroprotective Effects of Darbepoetin Alpha on the Hippocampus in Experimental Ethanol Administration 

  Uygur, Emine; Seymen, Hakkı Oktay; Uzun, Hafize; Tunçdemir, Matem; Öz, Aysim Buğe; Polat, Elif; Yılmaz, Ahsen; Yaman, Elif (Wiley, 2023)

• The Effect of Virus-Specific Vaccination on Laboratory Infection Markers of Children with Acute Rotavirus-Associated Acute Gastroenteritis 

  Okuyan, Ömer; Elgörmüş, Yusuf; Sayili, Ugurcan; Dumur, Şeyma; Işık, Özlem Erkan; Uzun, Hafize (Mdpi, 2023)

  Objective: Rotavirus (RV) is one of the most common and important causes of acute gastroenteritis (AGE) in newborns and children worldwide. The aim of this study was to evaluate the effect of the RV vaccine on the natural ...

• Significance of Cyclooxgenase-2 gene polymorphism and related miRNAs in pulmonary arterial hypertension 

  Durmuş, Sinem; Atahan, Ersan; Avcı Kılıçkıran, Burçak; Önal, Burak; Çakatay, Ufuk; Gelişgen, Remise; Uzun, Hafize (Elsevier, 2022)

  Background: Pulmonary arterial hypertension (PAH) is a rare disease with a poor prognosis. The suppression of cyclooxygenase-2 (COX-2) expression has been known to impair vascular function in endothelial cells; however, ...

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