Kurum Yazarı "Uzun, Hafize" Temel Tıp Bilimleri Bölümü Koleksiyonu İçin Listeleme
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The Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes
Fenercioglu, Aysen Kutan; Gonen, Mustafa Sait; Uzun, Hafize; Sipahioglu, Nurver Turfaner; Can, Gunay; Tas, Ebru; Kara, Zehra (Mdpi, 2023)In this study, we aimed to reveal the pro-inflammatory effects of serum 25-hydroxyvitamin D3 (Vit D) deficiency and insufficiency in new-onset type 2 diabetes mellitus (T2DM) and prediabetes. We recruited 84 prediabetes ... -
Can circulating oxidative stress-related biomarkers be used as an early prognostic marker for COVID-19?
Uysal, Pelin; Yüksel, Arzu; Durmuş, Sinem; Cuhadaroglu, Cağlar; Gelişgen, Remise; Uzun, Hafize (Frontiers Media Sa, 2023)Arka Plan Oksidatif stres birçok hastalığın patogenezinde önemli bir rol oynar. Bu çalışma, yeni COVİD-19 hastalarında nükleer faktör kappa B (NF-kappa B) ile oksidatif stres arasındaki ilişkiyi ve hastalığın ciddiyetini ... -
Circulating mir-132, mir-146a, mir-222, and mir-320 expression in differential diagnosis of women with polycystic ovary syndrome
Soyman, Zeynep; Durmuş, Sevgi Yaşar; Şimşek, Güven; Uzun, Hafize; Vivona, Sal (Acta Endocrinologica-Bucharest, 2022)Purpose. The aim of the study was to investigate whether the circulating miR-132, miR-146a, miR-222, and miR-320 levels are used in the differential diagnosis of women with polycystic ovary syndrome (PCOS) and ... -
The clinical significance of circulating mir-21, mir-142, mir-143, and mir-146a ın patients with prostate cancer
Adıgüzel, Mutlu; Konukoğlu, Dildar; Uzun, Hafize; Kurtuluş, Eda Merve; Bolayırlı, İbrahim Murat (Society of Medical Biochemists of Serbia, 2022)Background: Prostate cancer (PCa) is the most common type of solid tissue cancer among men in western countries. In this study, we determined the levels of circulating miR-21, miR-142, miR-143, miR-146a, and RNU 44 levels ... -
The Effect of Virus-Specific Vaccination on Laboratory Infection Markers of Children with Acute Rotavirus-Associated Acute Gastroenteritis
Okuyan, Ömer; Elgörmüş, Yusuf; Sayili, Ugurcan; Dumur, Şeyma; Işık, Özlem Erkan; Uzun, Hafize (Mdpi, 2023)Objective: Rotavirus (RV) is one of the most common and important causes of acute gastroenteritis (AGE) in newborns and children worldwide. The aim of this study was to evaluate the effect of the RV vaccine on the natural ... -
Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy
Doğan, Zeki; Ergun, D. D.; Durmus, S.; Şahin, Hilal; Şentürk, G. E.; Gelişgen, Remise; Senyigit, A.; Uzun, Hafize (Verduci Publisher, 2023)Objective: Oxidative stress and hypoxia play an important role in the pathogenesis of various cardiovascular diseases. We aimed to evaluate the effectiveness of sacubitril/valsartan (S/V) and Empagliflozin (EMPA) on ... -
Importance of oxidative stress in the evaluation of acute pulmonary embolism severity
Sağcan, Gülseren; Konukoğlu, Dildar; Uzun, Hafize; Arseven, Orhan; Okumuş, Gülfer; Çuhadaroğlu, Çağlar (BMC Pulmonary Medicine, 2022)Background: Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Our study was aimed to investigate whether oxidative stress markers can be used as clinical markers in the evaluation of acute ... -
Maternal serum preptin levels in the pathogenesis and diagnosis of gestational diabetes mellitus
Kıraç Utku, İrem; Demir, Esra; Özkan, Hanişe; Sahtiyancı, Berrak; Uzun, Hafize; Ekinci, İskender; Büyükkaba, Mitat; Durmuş, Sinem; Akarsu, Murat; Gelişgen, Remise; Tabak, Ömür (Society of Medical Biochemists of Serbia, 2023)Background: Gestational diabetes mellitus (GDM) is a metabolic disorder that occurs during pregnancy that increases both maternal and fetal mortality and morbidity. It was investigated whether there is a change in circulating ... -
Prediction of Preterm Delivery Using Serum Ischemia Modified Albumin, Biglycan, and Decorin Levels in Women with Threatened Preterm Labor
Bıyık, İsmail; Soysal, Cenk; İnce, Özlem Ulaş Onur; Durmuş, Sinem; Öztaş, Efser; Keskin, Nadi; Işıklar, Özben Özden; Karaağaç, Oğuz Han; Gelişgen, Remise; Uzun, Hafize (Georg Thieme Verlag KG, 2023)Objective The serum ischemia modified albumin (IMA), biglycan, and decorin levels of pregnant women who were hospitalized for threatened preterm labor were measured.Methods Fifty-one consecutive pregnant women with a single ... -
The relationship between hematological indices as indicators of inflammation and 25-hydroxyvitamin D3 status in newborns
Uzun, Hafize; Elgörmüş, Yusuf; Okuyan, Ömer (National Library of Medicine, 2023)Arka Plan Yenidoğanlarda hematolojik parametreler ile D vitamini durumu arasındaki ilişki hakkında hala pek çok şey bilinmemektedir. Çalışmanın amacı 25(OH)D3 (D vitamini) durumu ile yeni tanımlanmış sistemik inflamatuar ... -
Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD
Uysal, Pelin; Teksöz, Duygu; Aksan, Hülya; Durmuş, Sinem; Gelişgen, Remise; Şimşek, Gönül; Uzun, Hafize (Lippincott Williams & Wilkins, 2022)Our aim in this study was to evaluate the prognostic significance of sialic acid (SA) and prolidase activity and to evaluate the association between airflow obstruction severity and these parameters in chronic obstructive ... -
The Role of Glycogen Synthase Kinase-3β in the Zinc-Mediated Neuroprotective Effect of Metformin in Rats with Glutamate Neurotoxicity
Oruc, Aykut; Oruc, Kadriye Yagmur; Yanar, Karolin; Mengi, Murat; Caglar, Aysel; Kurt, Bahar Öztürk; Altan, Mehmet; Sönmez, Osman Fuat; Cakatay, Ufuk; Uzun, Hafize; Simsek, Gönül (Wiley, 2023)Metformin has been suggested to have protective effects on the central nervous system, but the mechanism is unknown. The similarity between the effects of metformin and the inhibition of glycogen synthase kinase (GSK)-3β ... -
The role of laparoscopic sleeve gastrectomy on inflammatory parameters n morbidly obese patients
Ergun, S.; Ergun, D. D.; Akıncı, O.; Taşkın, Halit Eren; Simsek, Gönül; Taşkın, M.; Uzun, Hafize (Elsevier Masson, Corp Off, 2022)Background: Obesity is an excessive increase in body fat mass and triggers chronic inflammation which causes increased fat accumulation in the visceral fat tissue. The aim of this study was to analyze serum zinc (Zn), ... -
The Role of NF-κB, PPAR-α, and PPAR-γ in Older Adults with Metabolic Syndrome
Demirağ, Filiz; Yavuzer, Serap; Cengiz, Mahir; Yavuzer, Hakan; Kara, Zehra; Ayvacı, Adnan; Avcı, Suna; Yürüyen, Mehmet; Uzun, Hafize; Altıparmak, Mehmet Rıza (Georg Thieme Verlag KG, 2023)The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood yet, and chronic low-grade inflammation is thought to be associated with the development of complications related to MetS. We aimed to investigate ... -
Serum and intestinal tissue zonulin levels in the evaluation of intestinal permeability in rats with acute pancreatitis
Yıldız, Abdullah; Kundaktepe, Berrin Papila; Yüksekdağ, Sema; Durmuş, Sinem; Silav, Zuhal Kuş; Gelişgen, Remise; Ünal, Ethem; Uzun, Hafize (2022)To evaluate the eff ects on malondialdehyde (MDA), superoxide dismutase (SOD), lipid hydroperoxide (LOOH), glutathione (GSH) levels as oxidative stress markers, zonulin levels, and histopathological findings of experimental ... -
Significance of Cyclooxgenase-2 gene polymorphism and related miRNAs in pulmonary arterial hypertension
Durmuş, Sinem; Atahan, Ersan; Avcı Kılıçkıran, Burçak; Önal, Burak; Çakatay, Ufuk; Gelişgen, Remise; Uzun, Hafize (Elsevier, 2022)Background: Pulmonary arterial hypertension (PAH) is a rare disease with a poor prognosis. The suppression of cyclooxygenase-2 (COX-2) expression has been known to impair vascular function in endothelial cells; however, ... -
Thrombospondin 1 and Nuclear Factor Kappa B Signaling Pathways in Non-alcoholic Fatty Liver Disease
Ekinci, İskender; Dumur, Şeyma; Uzun, Hafize; Anataca, Gulden; Yalcinkaya, İsa; Büyükkaba, Mitat (Medıcal Unıv Press, 2022)Amaç: Alkolsüz yağlı karaciğer hastalığında (NAFLD) dolaşımdaki trombospondin-1 (TSP-1) ve nükleer faktör kappa B'yi (NF-κB) bu sinyal yolaklarını karaciğerin inflamatuar ve fibrojenik süreçlerine entegre etmek amacıyla ...