Circulating mir-132, mir-146a, mir-222, and mir-320 expression in differential diagnosis of women with polycystic ovary syndrome
Künye
Soyman Z, Durmuş S, Ateş S, Simşek G, Sözer V, Kundaktepe BP, Kurtuluş D, Gelişgen R, Sal V, Uzun H. (2022). Circulating mir-132, mir-146a, mir-222, and mir-320 expression in differential diagnosis of women with polycystic ovary syndrome, Acta Endocrinologica-Bucharest, 18(1), pp. 13-19 https://doi.org/10.4183/aeb.2022.13 Özet
Purpose. The aim of the study was to investigate
whether the circulating miR-132, miR-146a, miR-222, and
miR-320 levels are used in the differential diagnosis of
women with polycystic ovary syndrome (PCOS) and healthy
women.
Methods. This prospective case-control study
included 50 women with PCOS and age- and body mass
index- matched 50 healthy controls. The hormone and lipid
profiles, levels of microRNAs (miRNAs), and parameters of
carbohydrate metabolism were measured.
Results. Expression levels of miRNAs were
assessed using the two-step quantitative real-time polymerase
chain reaction. Circulating miR-132, miR-146a and miR222 levels were significantly downregulated in the PCOS
group compared with the control group. The miR-320 levels
did not differ between the two groups. Free testosterone was
negatively correlated with miR-132, miR-146a and miR-222.
Insulin was negatively correlated with miR-132 and miR-146a.
Conclusions. The results of the study revealed
that miRNA expression, may suggest a possible distinction
between healthy women and PCOS patients. miR-132,
miR-146a, and miR-222 may have key functions in the
pathogenesis of PCOS.
