Kurum Yazarı "Uzun, Hafize" İçin Listeleme
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The Association Between Depression and Antidiabetic Treatments in Type 2 Diabetes Patients with Both Good and Poor Glycemic Control
Gümüşkaya, Perihan Özkan; Altun, Özgür; Yıldırım, Emine; Yüztaş, Nur Karakütük; Özsoy, Neslihan; Kalyon, Semih; Irak, Leyla; Özcan, Mustafa; Altun, Zeren Öztürk; Demir, Pınar Saner; Uzun, Hafize (MDPI, 2025)Background: Much research has demonstrated that there is a relation between depression and chronic diseases. Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases, and it is an expanding global health ... -
The Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes
Fenercioglu, Aysen Kutan; Gonen, Mustafa Sait; Uzun, Hafize; Sipahioglu, Nurver Turfaner; Can, Gunay; Tas, Ebru; Kara, Zehra (Mdpi, 2023)In this study, we aimed to reveal the pro-inflammatory effects of serum 25-hydroxyvitamin D3 (Vit D) deficiency and insufficiency in new-onset type 2 diabetes mellitus (T2DM) and prediabetes. We recruited 84 prediabetes ... -
Association between serum irisin concentration and ischemic stroke: From etiology to clinic
Çalık, Mustafa; Şengül, Yıldızhan; Gürkan, Zahide Mail; Hintoglu, Deniz; Mısırlıoğlu, Naile Fevziye; Uzun, Hafize (Society of Medical Biochemists of Serbia, 2022)Background: To investigate the relationship between irisin levels in serum and classification of subtype of acute ischemic stroke, National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Score (mRS) at the ... -
Association Between Serum Irisin Levels and ST-Segment Elevation Myocardial Infarction
Öztürk, Derya; Melekoğlu, Adem; Altınkiler, Ertuğrul; Çalık, Mustafa; Kösem, Arzu; Kilci, Hakan; Mısırlıoğlu, Naile Fevziye; Uzun, Hafize (Dove Medical Press Ltd, 2023)Background: An acute ST-elevation myocardial infarction (STEMI) is a serious cardiovascular condition with a high risk of morbidity and mortality. Irisin is adipomyokine that is associated with various health conditions. ... -
Association of Comorbidity and Inflammatory and Nutritional Markers with Epilepsy and Seizure Frequency
Aygün, Demet; Uzun, Hafize (MDPI, 2025)Background: Epilepsy is a chronic neurological disorder frequently influenced by systemic inflammation, nutritional status, and comorbid conditions, which may worsen seizure outcomes. Given the increasing recognition of ... -
Association of Helicobacter pylori with Serum HIF-1α, HIF-2α, and Human Transmembrane Prolyl 4-Hydroxylase Activity in Patients with Chronic Gastritis
Ergün, Sefa; Kutluk, Fadime; Turgut, Başar Can; Sayılı, Uğurcan; Ergün, Dilek Düzgün; Uzun, Hafize; Dümür, Şeyma (MDPI, 2025)Background and Objectives: Chronic mucosal infection with Helicobacter pylori (H. pylori) plays a key role in the development of gastroduodenal disorders such as chronic gastritis, peptic ulcers, gastric lymphoma, and ... -
Association of nutritional status indices with clinical outcomes in acute pancreatitis
Genç, Meltem; Duran, Eda Nur; Ekinci, İskender; Bayram, Mehmet; Uzun, Hafize; Tabak, Ömür (FRONTIERS MEDIA SA, 2025)Background/Objectives: Acute pancreatitis (AP) is an inflammatory condition marked by pancreatic tissue damage due to the activation of digestive enzymes in the pancreas, triggered by various factors. Nutritional status ... -
The Associations between Asprosine, Clusterin, Zinc Alpha-2-Glycoprotein, Nuclear Factor Kappa B, and Peroxisome Proliferator-Activated Receptor Gamma in the Development of Complications in Type 2 Diabetes Mellitus
Şenyiğit, Abdulhalim; Durmuş, Sinem; Tabak, Ömür; Oruç, Aykut; Uzun, Hafize; Ekinci, İskender (MDPI, 2024)Objectives: The aim of this study was to investigate the circulating levels of asprosin, clusterin, zinc-alpha-2-glycoprotein (ZAG), nuclear factor-kappa B (NF-kappa B), and peroxisome proliferator-activated receptor-gamma ... -
Can circulating oxidative stress-related biomarkers be used as an early prognostic marker for COVID-19?
Uysal, Pelin; Yüksel, Arzu; Durmuş, Sinem; Cuhadaroglu, Cağlar; Gelişgen, Remise; Uzun, Hafize (Frontiers Media Sa, 2023)Arka Plan Oksidatif stres birçok hastalığın patogenezinde önemli bir rol oynar. Bu çalışma, yeni COVİD-19 hastalarında nükleer faktör kappa B (NF-kappa B) ile oksidatif stres arasındaki ilişkiyi ve hastalığın ciddiyetini ... -
Circulating mir-132, mir-146a, mir-222, and mir-320 expression in differential diagnosis of women with polycystic ovary syndrome
Soyman, Zeynep; Durmuş, Sevgi Yaşar; Şimşek, Güven; Uzun, Hafize; Vivona, Sal (Acta Endocrinologica-Bucharest, 2022)Purpose. The aim of the study was to investigate whether the circulating miR-132, miR-146a, miR-222, and miR-320 levels are used in the differential diagnosis of women with polycystic ovary syndrome (PCOS) and ... -
The clinical significance of circulating mir-21, mir-142, mir-143, and mir-146a ın patients with prostate cancer
Adıgüzel, Mutlu; Konukoğlu, Dildar; Uzun, Hafize; Kurtuluş, Eda Merve; Bolayırlı, İbrahim Murat (Society of Medical Biochemists of Serbia, 2022)Background: Prostate cancer (PCa) is the most common type of solid tissue cancer among men in western countries. In this study, we determined the levels of circulating miR-21, miR-142, miR-143, miR-146a, and RNU 44 levels ... -
CLINICAL SIGNIFICANCE OF SERUM SYNAPTOPHYSIN-LIKE 1 PROTEIN LEVELS IN BREAST CANCER
Kösem, Yağmur Özge Turaç; Uzun, Hafize; Velidedeoğlu, Mehmet; Kocael, Pınar; Dümür, Şeyma; Şimşek, Osman (SOC MEDICAL BIOCHEMISTS SERBIA, 2024)Background: Mammography, used for breast cancer (BC) screening, has limitations such as decreased sensitivity in dense breasts. Currently used tumor markers are insufficient in diagnosing breast cancer. In this study, we ... -
Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis
Gümüşkaya, Perihan Özkan; Yıldırım, Emine; Altun, Özgür; Uzun, Hafize (MDPI, 2025)Background and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary ... -
Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
Uzun, Nedim; Gündoğar, Özgecan; Mısırlıoğlu, Naile; Yıldırım, Emine; Şahin, Neslin; Dümür, Şeyma; Uzun, Hafize (DE GRUYTER POLAND SP Z O O, 2025)Objectives Accurate diagnosis of acute cholecystitis (AC) is critical because early laparoscopic cholecystectomy significantly reduces complications and mortality. This study evaluates the predictive value of inflammatory ... -
Dysfunction of PTEN-Associated MicroRNA Regulation: Exploring Potential Pathological Links in Type 1 Diabetes Mellitus
Şenyiğit, Abdulhalim; Durmuş, Sinem; Oruç, Aykut; Gelişgen, Remise; Uzun, Hafize; Tabak, Ömür (MDPI, 2024)Background and Objectives: Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease with T cell-mediated pathogenesis of pancreatic β-cell destruction, leading to insulin deficiency. MicroRNAs such as miR-223 and miR-106b, ... -
The Effect of Virus-Specific Vaccination on Laboratory Infection Markers of Children with Acute Rotavirus-Associated Acute Gastroenteritis
Okuyan, Ömer; Elgörmüş, Yusuf; Sayili, Ugurcan; Dumur, Şeyma; Işık, Özlem Erkan; Uzun, Hafize (Mdpi, 2023)Objective: Rotavirus (RV) is one of the most common and important causes of acute gastroenteritis (AGE) in newborns and children worldwide. The aim of this study was to evaluate the effect of the RV vaccine on the natural ... -
Effects of Bosentan on Hypoxia, Inflammation and Oxidative Stress in Experimental Blunt Thoracic Trauma Model
Uzun, Nedim; Durmuş, Sinem; Gerçel, Gonca; Aksu, Burhan; Mısırlıoğlu, Naile Fevziye; Uzun, Hafize (MDPI, 2024)Background and Objectives: In this study, we aimed to investigate the effects of bosentan, an endothelin receptor antagonist, on endothelin-1 (ET-1), hypoxia-inducible factor-1 (HIF-1), nuclear factor-kappa B (NF-kappa B), ... -
The Effects of L-Ascorbic Acid on Isoniazid-Induced Protein Oxidation and Hepatotoxicity in Rats
Genç, Habibe; Dümür, Şeyma; Ergül, Yakup; Elgörmüş, Yusuf; Uzun, Hafize (İstanbul Atlas Üniversitesi, 2024)Isoniazid (INH) is hepatotoxic drug. Oxidative stress has been reported as one of the mechanisms of INH induced hepatotoxicity. In the current study, our aim was to evaluate the redox status of plasma and liver proteins ... -
Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy
Doğan, Zeki; Ergun, D. D.; Durmus, S.; Şahin, Hilal; Şentürk, G. E.; Gelişgen, Remise; Senyigit, A.; Uzun, Hafize (Verduci Publisher, 2023)Objective: Oxidative stress and hypoxia play an important role in the pathogenesis of various cardiovascular diseases. We aimed to evaluate the effectiveness of sacubitril/valsartan (S/V) and Empagliflozin (EMPA) on ...
