Yazar "Uzun, Hafize" için listeleme
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The Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes
Fenercioglu, Aysen Kutan; Gonen, Mustafa Sait; Uzun, Hafize; Sipahioglu, Nurver Turfaner; Can, Gunay; Tas, Ebru; Kara, Zehra (Mdpi, 2023)In this study, we aimed to reveal the pro-inflammatory effects of serum 25-hydroxyvitamin D3 (Vit D) deficiency and insufficiency in new-onset type 2 diabetes mellitus (T2DM) and prediabetes. We recruited 84 prediabetes ... -
Association between serum irisin concentration and ischemic stroke: From etiology to clinic
Çalık, Mustafa; Şengül, Yıldızhan; Gürkan, Zahide Mail; Hintoglu, Deniz; Mısırlıoğlu, Naile Fevziye; Uzun, Hafize (Society of Medical Biochemists of Serbia, 2022)Background: To investigate the relationship between irisin levels in serum and classification of subtype of acute ischemic stroke, National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Score (mRS) at the ... -
Association Between Serum Irisin Levels and ST-Segment Elevation Myocardial Infarction
Öztürk, Derya; Melekoğlu, Adem; Altınkiler, Ertuğrul; Çalık, Mustafa; Kösem, Arzu; Kilci, Hakan; Mısırlıoğlu, Naile Fevziye; Uzun, Hafize (Dove Medical Press Ltd, 2023)Background: An acute ST-elevation myocardial infarction (STEMI) is a serious cardiovascular condition with a high risk of morbidity and mortality. Irisin is adipomyokine that is associated with various health conditions. ... -
The Associations between Asprosine, Clusterin, Zinc Alpha-2-Glycoprotein, Nuclear Factor Kappa B, and Peroxisome Proliferator-Activated Receptor Gamma in the Development of Complications in Type 2 Diabetes Mellitus
Şenyiğit, Abdulhalim; Durmuş, Sinem; Tabak, Ömür; Oruç, Aykut; Uzun, Hafize; Ekinci, İskender (MDPI, 2024)Objectives: The aim of this study was to investigate the circulating levels of asprosin, clusterin, zinc-alpha-2-glycoprotein (ZAG), nuclear factor-kappa B (NF-kappa B), and peroxisome proliferator-activated receptor-gamma ... -
Can circulating oxidative stress-related biomarkers be used as an early prognostic marker for COVID-19?
Uysal, Pelin; Yüksel, Arzu; Durmuş, Sinem; Cuhadaroglu, Cağlar; Gelişgen, Remise; Uzun, Hafize (Frontiers Media Sa, 2023)Arka Plan Oksidatif stres birçok hastalığın patogenezinde önemli bir rol oynar. Bu çalışma, yeni COVİD-19 hastalarında nükleer faktör kappa B (NF-kappa B) ile oksidatif stres arasındaki ilişkiyi ve hastalığın ciddiyetini ... -
Circulating mir-132, mir-146a, mir-222, and mir-320 expression in differential diagnosis of women with polycystic ovary syndrome
Soyman, Zeynep; Durmuş, Sevgi Yaşar; Şimşek, Güven; Uzun, Hafize; Vivona, Sal (Acta Endocrinologica-Bucharest, 2022)Purpose. The aim of the study was to investigate whether the circulating miR-132, miR-146a, miR-222, and miR-320 levels are used in the differential diagnosis of women with polycystic ovary syndrome (PCOS) and ... -
The clinical significance of circulating mir-21, mir-142, mir-143, and mir-146a ın patients with prostate cancer
Adıgüzel, Mutlu; Konukoğlu, Dildar; Uzun, Hafize; Kurtuluş, Eda Merve; Bolayırlı, İbrahim Murat (Society of Medical Biochemists of Serbia, 2022)Background: Prostate cancer (PCa) is the most common type of solid tissue cancer among men in western countries. In this study, we determined the levels of circulating miR-21, miR-142, miR-143, miR-146a, and RNU 44 levels ... -
CLINICAL SIGNIFICANCE OF SERUM SYNAPTOPHYSIN-LIKE 1 PROTEIN LEVELS IN BREAST CANCER
Kösem, Yağmur Özge Turaç; Uzun, Hafize; Velidedeoğlu, Mehmet; Kocael, Pınar; Dümür, Şeyma; Şimşek, Osman (SOC MEDICAL BIOCHEMISTS SERBIA, 2024)Background: Mammography, used for breast cancer (BC) screening, has limitations such as decreased sensitivity in dense breasts. Currently used tumor markers are insufficient in diagnosing breast cancer. In this study, we ... -
Dysfunction of PTEN-Associated MicroRNA Regulation: Exploring Potential Pathological Links in Type 1 Diabetes Mellitus
Şenyiğit, Abdulhalim; Durmuş, Sinem; Oruç, Aykut; Gelişgen, Remise; Uzun, Hafize; Tabak, Ömür (MDPI, 2024)Background and Objectives: Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease with T cell-mediated pathogenesis of pancreatic β-cell destruction, leading to insulin deficiency. MicroRNAs such as miR-223 and miR-106b, ... -
The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease
Gökçe, Aylin Hande; Gökçe, Feridun Suat; Durmuş, Sinem; Hajiyeva, Ramila; Ersöz, Feyzullah; Gelişgen, Remise; Uzun, Hafize (Assoc Medica Brasileira, 2020)AIM: The aim of this study was to examine the roles of nitric oxide (NOx), endothelial nitric oxide synthetase (eNOS), and asymmetric dimethylarginine (ADMA), which is the major endogenous inhibitor of nitric oxide synthases ... -
The Effect of Virus-Specific Vaccination on Laboratory Infection Markers of Children with Acute Rotavirus-Associated Acute Gastroenteritis
Okuyan, Ömer; Elgörmüş, Yusuf; Sayili, Ugurcan; Dumur, Şeyma; Işık, Özlem Erkan; Uzun, Hafize (Mdpi, 2023)Objective: Rotavirus (RV) is one of the most common and important causes of acute gastroenteritis (AGE) in newborns and children worldwide. The aim of this study was to evaluate the effect of the RV vaccine on the natural ... -
Effects of Bosentan on Hypoxia, Inflammation and Oxidative Stress in Experimental Blunt Thoracic Trauma Model
Uzun, Nedim; Durmuş, Sinem; Gerçel, Gonca; Aksu, Burhan; Mısırlıoğlu, Naile Fevziye; Uzun, Hafize (MDPI, 2024)Background and Objectives: In this study, we aimed to investigate the effects of bosentan, an endothelin receptor antagonist, on endothelin-1 (ET-1), hypoxia-inducible factor-1 (HIF-1), nuclear factor-kappa B (NF-kappa B), ... -
The Effects of L-Ascorbic Acid on Isoniazid-Induced Protein Oxidation and Hepatotoxicity in Rats
Genç, Habibe; Dümür, Şeyma; Ergül, Yakup; Elgörmüş, Yusuf; Uzun, Hafize (İstanbul Atlas Üniversitesi, 2024)Isoniazid (INH) is hepatotoxic drug. Oxidative stress has been reported as one of the mechanisms of INH induced hepatotoxicity. In the current study, our aim was to evaluate the redox status of plasma and liver proteins ... -
Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy
Doğan, Zeki; Ergun, D. D.; Durmus, S.; Şahin, Hilal; Şentürk, G. E.; Gelişgen, Remise; Senyigit, A.; Uzun, Hafize (Verduci Publisher, 2023)Objective: Oxidative stress and hypoxia play an important role in the pathogenesis of various cardiovascular diseases. We aimed to evaluate the effectiveness of sacubitril/valsartan (S/V) and Empagliflozin (EMPA) on ... -
The Epidemiology of Deficiency of Vitamin B12 in Preschool Children in Turkey
Elgörmüş, Yusuf; Okuyan, Ömer; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize (MDPI, 2023)Background: Vitamin B12 is a water-soluble vitamin with important cellular functions; it is an essential vitamin. The aim of this study is to determine the B12 levels of children in the period from the 6th month when ... -
Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice
Okuyan, Ömer; Dümür, Şeyma; Elgörmüş, Neval; Uzun, Hafize (MDPI, 2024)Background and Objectives: To evaluate the clinical findings of glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiency in prolonged jaundice and to determine whether the systemic immune inflammation ... -
Evaluation of new generation systemic immune-inflammation markers to predict urine culture growth in urinary tract infection in children
Elgörmüş, Yusuf; Okuyan, Ömer; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize (FRONTIERS MEDIA SA, 2023)ObjectiveSystemic inflammation has been implicated in the development and progression of urinary tract infection (UTI). Accordingly, the aim of this study is to determine whether the white blood cell (WBC), C-reactive ... -
Evaluation of the Effect of Early-Onset Steroid Treatment in the COVID-19-Positive Pregnant Women on Pregnancy Outcomes
Elgörmüş, Neval; Şenyiğit, Abdulhalim; Okuyan, Ömer; Bozkurt, Fatma; Sivri Aydın, Derya; Uzun, Hafize (MDPI, 2024)Objective: Coronavirus disease 2019 (COVID-19) is the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Acute respiratory distress and preterm delivery are the two major complications induced ... -
Evaluation of the relationship between monocyte to high-density lipoprotein cholesterol ratio and thrombus burden in patients with deep vein thrombosis
Doğan, Zeki; Bektaşoğlu, Gökhan; Dümür, Şeyma; Uzun, Hafize; Erden, İsmail; Yurtdaş, Mustafa (Revista da Associacao Medica Brasileira, 2023)Bu çalışmanın amacı, derin ven trombozlu hastalarda monosit sayısı ve yüksek yoğunluklu lipoprotein kolesterol düzeylerini ve oranlarını (monosit/yüksek yoğunluklu lipoprotein oranı) değerlendirmek ve tanı anında bu oranın ...
