Retrospective Analysis of Biochemical Markers in COVID-19 Intensive Care Unit Patients
Citation
Ketenci, S., Saraçoğlu, İ., Duranay, R., Elgörmüş, Ç. S., & Aynacıoğlu, A. Ş. (25.05.2022). Retrospective analysis of biochemical markers in COVID-19 intensive care unit patients. The Egyptian Journal of Bronchology, 16(1). pp. 1-7. https://doi.org/10.1186/s43168-022-00129-7 Abstract
Background: The aim of the study was to evaluate the presence and efects of hematological and biological parameters in the diagnosis of the disease by performing blood tests on COVID-19 patients admitted to the intensive care
unit (ICU).
Results: Biochemical parameters from the blood samples of 279 patients who were confrmed to have COVID-19 and
met the criteria for admission to the ICU were compared between discharged and deceased patients. Multiple logistic
regression analysis was performed in terms of mortality and probability of being discharged. The predictive value of
serum C-reactive protein (CRP), procalcitonin (PCT), lymphocyte, neutrophil, leucocyte, and platelet (PLT) levels was
evaluated by measuring the area under the receiver operating characteristic curve (AUROC).
Comparisons made according to deceased and survival patients results revealed that while no statistically signifcant
diference was observed between test groups lymphocyte and platelet-lymphocyte ratio values, statistically signifcant diference was found between the test groups regarding platelet, leukocyte, neutrophil, PCT, neutrophil-lymphocyte ratio (NLR), and thrombocyte count × neutrophil count/lymphocyte count (SII) values.
Conclusions: This study showed that biochemical parameters examined are important in determining the prognosis of the disease and may be useful in determining the direction of the treatment process and predicting the risk of
discharge or death after the initial evaluation of the patients in the ICU.