Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorAtaşlar, Emine Yavuz
dc.contributor.authorAltınbaş, Kürşat
dc.date.accessioned2025-10-13T11:53:35Z
dc.date.available2025-10-13T11:53:35Z
dc.date.issued2025en_US
dc.identifier.citationYavuz Ataşlar, E., & Altınbaş, K. (2025). A comprehensive examination of circadian rhythm and tryptophan pathway parameters: Assessing their role in predicting bipolar disorder in patients, siblings, and controls. Chronobiology International, 42(6), 755-769. https://doi.org/10.1080/07420528.2025.2509623en_US
dc.identifier.issn0742-0528
dc.identifier.urihttps://hdl.handle.net/20.500.12900/723
dc.description.abstractThe complex interplay between sleep, circadian rhythms, and tryptophan pathway metabolites in bipolar disorder (BD) remains poorly understood. This study examined these mechanisms in euthymic individuals with BD (n = 20), their unaffected siblings (n = 20), and healthy controls (n = 24). Subjective and objective sleep and circadian rhythm parameters were assessed using questionnaires and actigraphy, alongside plasma measurements of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), and quinolinic acid (QUIN). Compared to controls, both BD patients and siblings showed reduced sleep efficiency and increased wake after sleep onset. Patients had longer time in bed, whereas siblings had shorter total sleep time. Elevated KYN/TRP ratios were found in both groups. Higher 3-HAA levels predicted both BD and sibling status, while increased QUIN levels were specific to BD. Lasso regression identified 12 variables associated with BD and 6 with sibling status. These results suggest that altered tryptophan metabolism and circadian disruption may contribute to the pathophysiology of BD and familial risk, providing potential biomarkers for early identification and intervention.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.isversionof10.1080/07420528.2025.2509623en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectActigraphyen_US
dc.subjectBipolar disorderen_US
dc.subjectCircadian rhythmsen_US
dc.subjectEndophenotypeen_US
dc.subjectSleepen_US
dc.subjectTryptophan pathwayen_US
dc.titleA comprehensive examination of circadian rhythm and tryptophan pathway parameters: Assessing their role in predicting bipolar disorder in patients, siblings, and controlsen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorAltınbaş, Kürşat
dc.identifier.volume42en_US
dc.identifier.issue6en_US
dc.identifier.startpage755en_US
dc.identifier.endpage769en_US
dc.relation.journalCHRONOBIOLOGY INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster