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dc.contributor.authorGökçe, Aylin Hande
dc.contributor.authorGökçe, Feridun Suat
dc.contributor.authorDurmuş, Sinem
dc.contributor.authorHajiyeva, Ramila
dc.contributor.authorErsöz, Feyzullah
dc.contributor.authorGelişgen, Remise
dc.contributor.authorUzun, Hafize
dc.descriptionUzun, Hafize/0000-0002-1347-8498; Gokce, Feridun Suat/0000-0001-8597-5787; Gokce, Aylin Hande/0000-0003-1908-2889; durmus, sinem/0000-0002-9272-9098en_US
dc.descriptionPubMed: 32935809en_US
dc.description.abstractAIM: The aim of this study was to examine the roles of nitric oxide (NOx), endothelial nitric oxide synthetase (eNOS), and asymmetric dimethylarginine (ADMA), which is the major endogenous inhibitor of nitric oxide synthases (NOS), in the pathophysiology of hemorrhoidal disease. METHODS: This study included 54 patients with grades 3 and 4 internal hemorrhoidal disease and 54 patients without the disease who attended the General Surgery Clinic. NOx, eNOS, and ADMA levels were measured with the Enzyme-Linked ImmunoSorbent Assay (ELISA) method. RESULTS: The patients had higher NO and eNOS levels and lower ADMA levels than the control subjects (p<0.001). A significant highly positive correlation was found between NO and eNOS (p<0.001). Nevertheless, there was a highly negative correlation between ADMA and NO-eNOS(p<0.001, p<0.001). CONCLUSION: This preliminary study reveals that higher NOx and eNOS activities and lower ADMA levels in the rectal mucosa are observed in patients with hemorrhoidal disease than in those with normal rectal tissue. The imbalance between endothelium-derived relaxing factors, such as NO and endogenous competitive inhibitor of NOS, ADMA, may cause hemorrhoidal disease. Our study proposes that hemorrhoids display apparent vascular dilatation and present with bleeding orswelling. ADMA is an effective NOS inhibitor and may be a promising therapeutic option for hemorrhoidal disease.en_US
dc.publisherAssoc Medica Brasileiraen_US
dc.subjectArginine/analogs & derivativesen_US
dc.subjectNitric oxide synthase type IIIen_US
dc.subjectNitric oxideen_US
dc.subjectNitric oxide synthaseen_US
dc.titleThe effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal diseaseen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.department-temp[Gokce, Aylin Hande] Istanbul Atlas Univ, Dept Gen Surg, Fac Med, Istanbul, Turkey; [Gokce, Feridun Suat] Balikli Rum Hosp, Dept Gen Surg, Istanbul, Turkey; [Durmus, Sinem; Hajiyeva, Ramila; Gelisgen, Remise; Uzun, Hafize] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Med Biochem, Istanbul, Turkey; [Ersoz, Feyzullah] Istanbul Training Res Hosp, Dept Gen Surg, Istanbul, Turkeyen_US
dc.contributor.institutionauthorGökçe, Aylin Hande
dc.relation.journalRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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