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dc.contributor.authorKurç, Mine Aydın
dc.contributor.authorGünaydın, Betül
dc.contributor.authorAkpınar, Seval
dc.contributor.authorŞafak, Birol
dc.contributor.authorKiraz, Nuri
dc.date.accessioned2024-10-24T06:54:09Z
dc.date.available2024-10-24T06:54:09Z
dc.date.issued2024en_US
dc.identifier.citationAydın Kurç, M., Günaydın, B., Akpınar, S., Şafak, B., & Kiraz, N. (2024). Invasive pulmonary aspergillosis evaluation in hematology patients: Three years results of tertiary hospital. Biomolecules and Biomedicine. https://doi.org/10.17305/bb.2024.10766en_US
dc.identifier.issn2831-0896
dc.identifier.urihttps://hdl.handle.net/20.500.12900/402
dc.description.abstractInvasive pulmonary aspergillosis (IPA) is the most frequent invasive fungal disease occurring in patients with hematological malignancies. Serum galactomannan (GM) antigen monitoring is thought to be helpful in the diagnosis of IPA. The aim of this study was to determine the role of a GM assay in serum samples for the diagnosis of IPA in patients with hematological disease. The data of 366 immunosuppressed patients that were hospitalized and followed up in the hematology clinic from January 2017 to December 2019 were retrospectively analyzed. The clinical and radiological findings of the patients and the GM results, requested twice a week, were evaluated. In this study, the incidence of probable and possible IPA was determined to be 15.3% (56/366). Of the cases detected, 28 (50.0%) were patients diagnosed with Acute Myeloid Leukemia (AML), and 34 (60.7%) patients who had compatible clinical and examination findings were started on antifungal treatment. Additionally, AUC (Area Under the Curve) values were calculated by ROC (Receiver Operating Characteristic) analysis, and it was determined that the diagnostic efficiency was more predictive when the cut-off was 0.5 in the GM test for IPA disease. The detection of GM antigen in serum is a very useful and rapid method for diagnosing IPA disease in immunosuppressed hematology patients. However, GM results should be evaluated together with clinical and radiological findings for early diagnosis, and the treatment approach should be determined accordingly.en_US
dc.language.isoengen_US
dc.publisherASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVOen_US
dc.relation.isversionof10.17305/bb.2024.10766en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInvasive pulmonary aspergillosisen_US
dc.subjectGalactomannan testingen_US
dc.subjectHematological malignancyen_US
dc.titleInvasive pulmonary aspergillosis evaluation in hematology patients: Three years results of tertiary hospitalen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesien_US
dc.authoridhttps://orcid.org/0000-0002-1796-4127en_US
dc.contributor.institutionauthorŞafak, Birol
dc.relation.journalBIOMOLECULES AND BIOMEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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