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dc.contributor.authorKösem, Yağmur Özge Turaç
dc.contributor.authorUzun, Hafize
dc.contributor.authorVelidedeoğlu, Mehmet
dc.contributor.authorKocael, Pınar
dc.contributor.authorDümür, Şeyma
dc.contributor.authorŞimşek, Osman
dc.date.accessioned2024-04-18T14:32:49Z
dc.date.available2024-04-18T14:32:49Z
dc.date.issued2024en_US
dc.identifier.citationTuraç Kösem, Y. Ö., Uzun, H., Velidedeğlu, M., Kocael, P., Dümür, Ş., & Şimşek, O. (2024). CLINICAL SIGNIFICANCE OF SERUM SYNAPTOPHYSIN-LIKE 1 PROTEIN LEVELS IN BREAST CANCER. JOURNAL OF MEDICAL BIOCHEMISTRY, 43(2), 273-280. https://doi.org/10.5937/jomb0-46198en_US
dc.identifier.issn1452-8266
dc.identifier.urihttps://hdl.handle.net/20.500.12900/367
dc.description.abstractBackground: Mammography, used for breast cancer (BC) screening, has limitations such as decreased sensitivity in dense breasts. Currently used tumor markers are insufficient in diagnosing breast cancer. In this study, we aimed to investigate the relationship between serum levels of synaptophysin-like protein 1 (SYPL1) and BC and compare SYPL1 with other blood tumor markers. Methods: The study group consisted of 80 female patients with a histopathological diagnosis of invasive BC who received no radiotherapy/chemotherapy. The control group was 72 women with no previous history of breast disease and evaluated as Breast Imaging Reporting and Data Systems (BI -RADS 1-2) on imaging. Serum SYPL1, cancer antigen 15-3 (CA 15-3), and carcinoembryonic antigen (CEA) were measured in both groups. Results: The diagnostic values of SYPL1, CEA, and CA153 proteins in diagnosing BC were statistically significant. The sensitivity of SYPL1 was 48.75%, with a specificity of 80.56%. CA15-3 had a sensitivity of 80% and a specificity of 49.30%. There was no statistically significant correlation between serum SYPL1 and tumor diameter, lymph node metastasis, distant organ metastasis, and stage. Conclusion: The serum SYPL1 maintained a higher discriminatory ability for BC. The serum SYPL1 level can be used with high specificity in diagnosing BC. However, SYPL1 has a low diagnostic value in BC by itself.en_US
dc.language.isoengen_US
dc.publisherSOC MEDICAL BIOCHEMISTS SERBIAen_US
dc.relation.isversionof10.5937/jomb0-46198en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSynaptophysin-like 1en_US
dc.subjectBreast canceren_US
dc.subjectDense breastsen_US
dc.subjectTumor markersen_US
dc.titleCLINICAL SIGNIFICANCE OF SERUM SYNAPTOPHYSIN-LIKE 1 PROTEIN LEVELS IN BREAST CANCERen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.authoridhttps://orcid.org/0000-0002-1347-8498en_US
dc.authoridhttps://orcid.org/0000-0001-8893-2926en_US
dc.contributor.institutionauthorUzun, Hafize
dc.contributor.institutionauthorDümür, Şeyma
dc.identifier.volume43en_US
dc.identifier.issue2en_US
dc.identifier.startpage273en_US
dc.identifier.endpage280en_US
dc.relation.journalJOURNAL OF MEDICAL BIOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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