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dc.contributor.authorSever, I. H.
dc.contributor.authorÖzkul, Bahattin
dc.contributor.authorAtasoy, Özüm
dc.contributor.authorCini, Nilsu
dc.contributor.authorBozkurt, Mehmet Fatih
dc.contributor.authorErdogan, M. A.
dc.contributor.authorYaprak, G
dc.contributor.authorErbaş, Oytun
dc.date.accessioned2024-02-29T12:10:19Z
dc.date.available2024-02-29T12:10:19Z
dc.date.issued2023en_US
dc.identifier.citationSever, Ibrahim & Özkul, Bahattin & Atasoy, Özüm & Cini, Nilsu & Bozkurt, Mehmet & Erdoğan, M. & Yaprak, Gökhan & Erbas, Oytun. (2023). Neuroprotective effect of polyethylene Glycol (PEG-3350) on radiation-induced brain injury via membrane stabilization. 21. 733-743. 10.52547/ijrr.21.4.19.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12900/321
dc.description.abstractBackground: This research aims to evaluate whether polyethylene glycol (PEG), which can immediately repair neuronal membranes, will have a protective effect against radiation-induced brain injury (RIBI). Materials and Methods: Whole brain irradiation (RAD) procedure was performed on 14 of 21 rats included in the study for establishing RIBI. Rats were randomly divided into three groups containing equal numbers of animals: control (RAD not established), placebo (RAD applied, and treated with 1 ml/ kg/day of saline that was administered intraperitoneally), and treatment (RAD applied, and treated with 30 mg/kg /day of PEG 3350 that was administered intraperitoneally). Following the end of the 22-day treatments, behavioral tests were performed first, and then magnetic resonance spectroscopy (MRS) was applied to measure brain lactate levels. All rats were sacrificed in order to perform biochemical analysis and histopathological examination of brain tissue. Results: Compared to the control group, MDA, TNF-alpha, NF -KB and lactate levels were significantly increased, while BDNF levels were decreased in the placebo group; and RAD-induced changes in all these biochemical markers were reversed by PEG. In MRS performed from the corpus striatum, there was an evident decrease in lactate levels after PEG treatment. Impairment in memory and learning was more limited in PEG-treated rats than in the rats receiving saline therapy. Furthermore, histological examinations from hippocampus and cerebellum exhibited that PEG treatment significantly reduces apoptosis, astrogliosis, and oxidative DNA damage in rats. Conclusion: Our results support that PEG is very effective in preventing RIBI with its secondary effects on the basis of membrane stabilization.en_US
dc.language.isoengen_US
dc.publisherIJRR - International Journal of Radiation Researchen_US
dc.relation.isversionof10.52547/ijrr.21.4.19en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadyasyonen_US
dc.subjectRadiationen_US
dc.subjectPEG-3350en_US
dc.subjectMRSen_US
dc.subject8-oxo-dGen_US
dc.subjectBDNFen_US
dc.subjectMembran stabilizasyonuen_US
dc.subjectMembrane stabilizationen_US
dc.titleNeuroprotective effect of polyethylene Glycol (PEG-3350) on radiation-induced brain injury via membrane stabilizationen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Ana Bilim Dalıen_US
dc.authoridBahattin Özkul/0000-0003-3339-8329en_US
dc.contributor.institutionauthorÖzkul, Bahattin
dc.identifier.volume21en_US
dc.identifier.issue4en_US
dc.identifier.startpage733en_US
dc.identifier.endpage743en_US
dc.relation.journalInternational Journal of Radiation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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