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dc.contributor.authorÖztürk, Derya
dc.contributor.authorMelekoğlu, Adem
dc.contributor.authorAltınkiler, Ertuğrul
dc.contributor.authorÇalık, Mustafa
dc.contributor.authorKösem, Arzu
dc.contributor.authorKilci, Hakan
dc.contributor.authorMısırlıoğlu, Naile Fevziye
dc.contributor.authorUzun, Hafize
dc.date.accessioned2024-01-12T07:53:07Z
dc.date.available2024-01-12T07:53:07Z
dc.date.issued2023en_US
dc.identifier.citationOzturk, D., Melekoglu, A., Altinbilek, E., Calik, M., Kosem, A., Kilci, H., Misirlioglu, N. F., & Uzun, H. (2023). Association Between Serum Irisin Levels and ST-Segment Elevation Myocardial Infarction. International journal of general medicine, 16, 1355–1362. https://doi.org/10.2147/IJGM.S403564en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12900/309
dc.description.abstractBackground: An acute ST-elevation myocardial infarction (STEMI) is a serious cardiovascular condition with a high risk of morbidity and mortality. Irisin is adipomyokine that is associated with various health conditions. In post-STEMI, elevated serum irisin levels are associated with more adverse cardiovascular events.Objective: The purpose of this study was to investigate associations between the serum irisin levels and acute MI (AMI) and whether irisin may be a useful biomarker for severity of AMI in patients with STEMI. Possible correlations between serum irisin and cardiac troponin-I (cTi) levels were investigated.Methods: A total of 90 subjects (46 control subjects and 44 STEMI patients) were included in the study. Besides demographic data, presence of diabetes mellitus and hypertension, electrocardiography (ECG) findings, blood biochemistry, cardiac biomarkers (cTi) and serum irisin levels were examined.Results: Significantly lower heart rate (HR) and significantly higher ST-elevation and QTc interval were detected in ECG recordings in STEMI patients (p < 0.05). Serum irisin levels were significantly lower in STEMI patients compared to the control subjects (p < 0.001). The decrease in the serum irisin levels was significantly correlated with the increase in cTi levels, as well as increased QTc (p < 0.05). The sensitivity and specificity of irisin were found to be 93% and 78%, respectively.Conclusion: Decreased irisin levels were found to be highly predictive in STEMI. In patients with STEMI, the serum irisin levels were associated with cTi levels and QTc, suggesting that irisin is a promising biomarker for AMI cases.en_US
dc.language.isoengen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.isversionof10.2147/IJGM.S403564en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMiyokardiyal enfarktüsen_US
dc.subjectMyocardial infarctionen_US
dc.subjectKardiyovasküler hastalıklaren_US
dc.subjectCardiovascular diseasesen_US
dc.subjectİrisin, troponin-I,en_US
dc.subjectQT aralığıen_US
dc.subjectQT intervalen_US
dc.subjectBiyobelirteçen_US
dc.subjectBiomarkeren_US
dc.titleAssociation Between Serum Irisin Levels and ST-Segment Elevation Myocardial Infarctionen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.authoridHafize Uzun/ 0000-0002-1347-8498en_US
dc.contributor.institutionauthorUzun, Hafize
dc.identifier.volume16en_US
dc.identifier.startpage1355-1362en_US
dc.identifier.endpage1355-1362en_US
dc.relation.journalInternational Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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