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dc.contributor.authorÖzkaya, Esra
dc.contributor.authorYazıcı, Merve
dc.contributor.authorBaran, Irmak
dc.contributor.authorÇetin, Nesibe Selma
dc.contributor.authorTosun, İlknur
dc.contributor.authorBuruk, Celal Kurtuluş
dc.contributor.authorKaklikkaya, Neşe
dc.contributor.authorAydın, Faruk
dc.contributor.authorDoymaz, Mehmet Ziya
dc.identifier.citationÖzkaya, E., Yazıcı, M., Baran, I., Çetin, N. S., Tosun, İ., Buruk, C. K., Kaklıkkaya, N., Aydın, F., & Doymaz, M. Z. (2023). Neutralization of Wild-Type and Alpha SARS-CoV-2 Variant by CoronaVac® Vaccine and Natural Infection- Induced Antibodies. Current microbiology, 80(5), 162.
dc.description.abstractOne of the immune responses desired to be achieved by SARS-CoV-2 vaccination is to create neutralizing antibodies (nAbs), thus preventing the development and spread of infection. The aim of this study was to investigate the seropositivity rate, anti-spike antibody levels, and neutralizing capacity of these antibodies against wild type (WT) and alpha variants in serum samples of individuals who had been naturally infected or vaccinated with CoronaVac®. Total anti-spike antibody levels were determined in all samples. Neutralization assays were performed by the reduction of the cytopathic efect in Vero-E6 cells with infectious WT and alpha SARS-CoV-2 variants. Although both naturally infected and vaccinated individuals were all seropositive for antispike antibodies, 84.8% of the vaccinated group, and 89.3% of the naturally infected group had detectable nAbs. The nAbs titers were signifcantly higher in the naturally infected group for both WT and alfa variant of the virus as compared to the vaccinated individuals. In this study, it was observed that all individuals became seropositive six weeks after exposure to the vaccine or the virus. Moreover, naturally infected individuals had higher levels of nAbs than those vaccinated. The presence of nAbs against the alpha variant in both naturally infected and vaccinated individuals suggests that these antibodies may also be protective against infections, which may be caused by other variants, such as delta and omicron.en_US
dc.titleNeutralization of Wild-Type and Alpha SARS-CoV-2 Variant by CoronaVac® Vaccine and Natural Infection- Induced Antibodiesen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorAydın, Faruk
dc.relation.journalCurrent Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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