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dc.contributor.authorÖzbek, Ayşe Elverdi
dc.contributor.authorKorkmaz, Hüseyin
dc.contributor.authorSözen, Mehmet
dc.contributor.authorİpekçi, Süleyman Hilmi
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorKıraç, Cem Onur
dc.identifier.citationÖzbek, A. E., Korkmaz, H., Sözen, M., İpekçi, S. H., Abuşoğlu, S., Kıraç, C. O., Ünlü, A., & Kebapçılar, L. (2022). Evaluation of Bone Turnover Markers Such as Osteoprotegerin, Sclerostin and Dickkopf-1 in Subclinical Hyperthyroidism. Indian Journal of Clinical Biochemistry. ‌en_US
dc.identifier.uriWOS: 000850397300008
dc.descriptionEarly Acsessen_US
dc.description.abstractIn this study, it was aimed to assess effects of subclinical hyperthyroidism (SH) on bone metabolism using osteoprotegerin (OPG), sclerostin, Dickkopf-1 (DKK1) and biochemical parameters. This cross-sectional prospective study included 40 patients with SH and 40 euthyroid controls. Serum OPG, sclerostin, DKK-1, type-1 procollagen, C-terminal polypeptide (CTx) and 24-hours urine N-terminal telopeptide (NTx) were measures using ELISA kit. Bone mineral density measurements were performed using dual energy X-ray absorptiometry (DEXA). Risk for 10-years hip and major fracture was estimated by Turkish version of FRAX. No significant difference was detected in age, gender, body mass index, smoking and menopause rates between SH and control groups. The risk for 10-years hip fracture and major osteoporotic fracture were estimated as 4.45% and 0.55% in SH group, respectively. The OPG levels were significantly lower in patients with SH than controls (P = 0.017). No significant difference was detected in other bone formation and degradation parameters. No significant correlation was detected between OPG level and risk for major osteoporotic fracture (P > 0.05); however, a negative correlation was detected between OPG level and risk for hip fracture (rho = 0.233; P = 0.038). Serum OPG is markedly affected in patients with SH. In addition, OPG seemed to be associated with osteoporotic fracture risk. Available data show that SH is significantly associated with risk for fracture; thus, it is important to assess risk for fracture in patients with SH.en_US
dc.publisherSpringer Natureen_US
dc.subjectSubclinical hyperthyroidismen_US
dc.subjectBone metabolismen_US
dc.titleEvaluation of Bone Turnover Markers Such as Osteoprotegerin, Sclerostin and Dickkopf-1 in Subclinical Hyperthyroidismen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.authoridSüleyman Hilmi İpekçi / 0000-0003-4410-2212en_US
dc.contributor.institutionauthorİpekçi, Süleyman Hilmi
dc.relation.journalIndian Journal of Clinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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