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dc.contributor.authorAdrovic, Amra
dc.contributor.authorBarut, Kenan
dc.contributor.authorKasapçopur, Özgür
dc.contributor.authorKucur, Mine
dc.contributor.authorDümür, Şeyma
dc.date.accessioned2023-01-10T08:05:45Z
dc.date.available2023-01-10T08:05:45Z
dc.date.issued2022en_US
dc.identifier.citationDumur, S., Adrovic, A., Barut, K., Kasapcopur, O., & Kucur, M. (2022). The role of S100A12 and Toll‐like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis. International Journal of Rheumatic Diseases. https://doi.org/10.1111/1756-185x.14475 ‌en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.urihttps://hdl.handle.net/20.500.12900/140
dc.descriptionKapalı Erişimen_US
dc.description.abstractObjective Our aim was to investigate the possible relationship between the serum S100A12 and Toll-like receptor 4 (TLR4) levels, and the activity of familial Mediterranean fever (FMF) and juvenile idiopathic arthritis (JIA) in accordance with the routine biochemical parameters. Furthermore, the effectiveness of these 2 biomarkers in distinguishing FMF from JIA has been evaluated. Method Sixty-nine children with FMF, 68 children with JIA, and 35 healthy children were included in this study. S100A12 and TLR4 levels were measured by the sandwich enzyme-linked immunosorbent assay technique. Results In the FMF patient group, serum S100A12 level was found to be significantly higher than in both the JIA and control groups (P = .000 and P = .000, respectively). Although S100A12 levels were higher in the attack period compared to the attack-free period, this increase was not statistically significant (P > .05). TLR4 levels were statistically significantly higher in the attack period compared to the attack-free period in children with FMF (P < .05). Although there was no relationship between S100A12 levels and disease activity, there is a clear correlation between S100A12 and the Auto-Inflammatory Disease Activity Index in attack-free FMF patients (r = 0.612 P = .000). Conclusion Serum S100A12 levels were not found to be a potentially valuable biomarker for assessing disease activity in either FMF or JIA. However, TLR4 levels were found to be a valuable biomarker for assessing disease activity in children with FMF. Further research which includes serial monitoring of S100A12 and TLR4 levels in a large cohort will provide detailed information about accuracy of these 2 potential biomarkers in both patients group.en_US
dc.language.isoengen_US
dc.publisherWiley Online Libraryen_US
dc.relation.isversionof10.1111/1756-185X.14475en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe role of S100A12 and Toll-like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritisen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.authoridŞeyma Dümür / 0000-0001-8893-2926en_US
dc.contributor.institutionauthorDümür, Şeyma
dc.identifier.volume26en_US
dc.identifier.issue1en_US
dc.relation.journalInternatıonal Journal Of Rheumatıc Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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