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dc.contributor.authorZincir, Özge Özdal
dc.contributor.authorÖzdal, Umut
dc.contributor.authorÜnlü, Özge
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorKatipoğlu, Ahmet Bülent
dc.contributor.authorEgil, Edibe
dc.contributor.authorŞallı, Gülay Altan
dc.date.accessioned2022-12-16T10:51:12Z
dc.date.available2022-12-16T10:51:12Z
dc.date.issued2021en_US
dc.identifier.citationÖzdal Zincir, Ö., Özdal, U., Ünlü, Ö., Demirci, M., Katiboğlu, A. B., Egil, E., & Altan Şallı, G. (2021). Synergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro study. Odontology, 110(2), pp. 330–337. https://doi.org/10.1007/s10266-021-00667-4 ‌en_US
dc.identifier.issn1618-1247
dc.identifier.issn1618-1255
dc.identifier.uriWOS: 000707922100001
dc.identifier.uriPubMed ID: 34657217
dc.identifier.urihttps://hdl.handle.net/20.500.12900/127
dc.description.abstractThe efectiveness of antifungal agents may be insufcient against resistant strains in some cases of oral candidiasis. The aim of this study was to evaluate the antifungal efect of thymoquinone against Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei strains and the synergistic antifungal activity of these strains in combination with nystatin. To evaluate in vitro antifungal activity and interactions between thymoquinone and nystatin, substances were tested against Candida albicans ATCC 10,231, C. tropicalis ATCC 750, C.krusei ATCC 6258 and C. glabrata ATCC 2001 standard strains both individually and combinationally via microdilution method. MIC and ΣFIC index value were analysed. The Kruskal Wallis test and Bonferroni test were used for statistical evaluations. Statistical signifcance was set at p<0.05. A statistically signifcant diference was observed between the mean ranks of all Candida species and doses of thymoquinone, nystatin, and the combination thymoquinone-nystatin (p<0.05). MIC values for thymoquinone were determined as 15 μg/mL for C. albicans, C. tropicalis and C. krusei while it was 30 μg/mL for C. glabrata. Moreover, MIC for nystatin was found as 1.875 μg/mL for C. albicans, C. tropicalis and C. krusei, whereas it was 7.5 μg/mL in C. glabrata. Interaction assays and ΣFIC index value revealed that, TQ and nystatin have a synergistic efect against to all strains. Thymoquinone was found to have antifungal activity on Candida species and synergistic efect when combined with nystatin.en_US
dc.language.isoengen_US
dc.publisherSpringer Openen_US
dc.relation.isversionof10.1007/s10266-021-00667-4en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectCandidaen_US
dc.subjectAntifungal drugsen_US
dc.subjectSynergistic efecten_US
dc.subjectOral candidiasisen_US
dc.titleSynergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro studyen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Diş Hekimliği Fakültesien_US
dc.authoridAhmet Bülent Katipoğlu / 0000-0001-7505-9953en_US
dc.contributor.institutionauthorKatipoğlu, Ahmet Bülent
dc.identifier.volume110en_US
dc.identifier.issue2en_US
dc.identifier.startpage330en_US
dc.identifier.endpage337en_US
dc.relation.journalOdontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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