Investigating antimicrobial features and drug interactions of sedoanalgesics in intensive care unit: an experimental study
Künye
Unlu, O., Bingul, E., Kesi̇ci̇S., & Demirci, M. (2021). Investigating antimicrobial features and drug interactions of sedoanalgesics in intensive care unit: an experimental study. ADMET and DMPK. (9)3, pp.219-226, https://doi.org/10.5599/admet.1042 Özet
Study Objective: Aim of this study was to evaluate antimicrobial effects and interaction between analgesic
combinations of fentanyl citrate, dexmedetomidine hydrochloride and tramadol hydrochloride on
Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Candida
albicans which are some of the most common nosocomial infection related microorganisms. Design: In
vitro prospective study. Setting: University Clinical Microbiology Laboratory. Measurements: In order to
evaluate in vitro antimicrobial effects and interaction between analgesic combinations, tramadol
hydrochloride, fentanyl citrate and dexmedetomidin were used against S. aureus ATCC 29213, K.
pneumoniae, E. coli ATCC 25922, P. aeruginosa ATCC 27853 and C. albicans ATCC 10231 standard strains by
microdilution method. Main Results: According to microdilution assays tramadol has shown the most
efficient antimicrobial activity also it has been observed that 10 g/ml concentrated dexmedetomidine has
antimicrobial effects on S. aureus, K. pneumoniae and P. aeruginosa. Fentanyl has displayed evident
inhibitory potency on the pathogens except for Klebsiella pneumoniae, nevertheless our predefined
minimum concentration inhibited growth by 9.5 %. Fentanyl and dexmedetomidine together exhibited
more antimicrobial effect on P. aeruginosa and E. coli growth. Additionally, when the three drugs
examined together, microbial inhibition occurred more than expected on E. coli again and also on C.
albicans growth. Conclusions: Our results revealed the antimicrobial properties and synergy with the
different combinations of fentanyl, dexmedetomidine and tramadol against the most common nosocomial
infection agents in the ICU. This is the first study in the literature looking into the microbial “interactions”
of opioids and sedative drugs but more research is needed in order to define clinico-laboratory correlation.