İstanbul Atlas University Institutional Repository

The Association Between Lithium Use and Physical Comorbidities Across Age Groups: A Cross-Sectional Study From the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project

Thu, 01 Jan 2026 00:00:00 GMT

The Association Between Lithium Use and Physical Comorbidities Across Age Groups: A Cross-Sectional Study From the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project Toprak, Çağla; Akbulut, Seda Cansu Yenigün; Kurtuluş, Neşe; Çavdar, İkbal Background Colonoscopy is a routinely employed procedure for the diagnosis and management of colorectal diseases. Despite its clinical utility, it is often associated with patient anxiety and discomfort, which may be exacerbated by procedure-related complications. Therefore, this study sought to evaluate and compare the effects of white and pink noise, administered both prior to and during colonoscopy, on anxiety and pain levels in adult patients undergoing colonoscopy. Methods This randomized controlled study was conducted with 135 participants undergoing colonoscopy. Participants were randomly assigned to one of three groups: White Noise (n = 45), Pink Noise (n = 45), and Control (n = 45). The White Noise and Pink Noise groups were exposed to continuous auditory stimulation (white or pink noise, respectively) for 20 min prior to the procedure and for an additional 20 min during the procedure. Data were analyzed using the Statistical Package for the Social Sciences SPSS v27. Results Post-intervention anxiety levels showed that all groups demonstrated statistically significant changes in anxiety scores over time (Control: p = 0.015; White Noise: p = 0.006; Pink Noise: p < 0.001). Notably, the pink noise group exhibited significantly lower anxiety levels compared to the other groups (p < 0.001). Pain scores were significantly lower in both the white noise and pink noise groups than in the control group during and after the procedure (all p < 0.001). However, no statistically significant difference was observed between the two noise intervention groups (p > 0.999). Conclusion In patients undergoing colonoscopy, the use of white and pink noise as adjuncts to pain management and psychological preparation may improve the quality of nursing care and patient outcomes, representing a low-cost, non-invasive, and easily implemented intervention. Trial registration NCT07034638 (Registration date: 24.06.2025) .

Statistical Geometric Morphometric Shape Analysis of Ventricular Shape Changes in Giant Pituitary Adenomas Invading the Third Ventricle

Thu, 01 Jan 2026 00:00:00 GMT

Statistical Geometric Morphometric Shape Analysis of Ventricular Shape Changes in Giant Pituitary Adenomas Invading the Third Ventricle Altunyuva, Oğuz; Balçın, Nur; Ocakoğlu, Gökhan; Taşkapılıoğlu, Mevlüt Özgür; Yılmazlar, Selçuk AIM: To investigate the preoperative, early and late postoperative differences in the anterior callosal angle, lateral and third ventricle shapes of patients with pituitary macroadenoma operated via the transsphenoidal approach. MATERIAL and METHODS: Shape data of the third and lateral ventricles were collected from the two-dimensional digital images. The generalised Procteus analysis was used to obtain mean shapes in the preoperative, early and late postoperative phases. The shape deformation of the ventricles from pre-to postoperative phases was evaluated using the thin plate spline method. Anterior callosal angle (ACA) was measured pre-to postoperative images and was analyzed statistically. RESULTS: There was no significant lateral ventricle shape and ACA measurement difference in the pre and postoperative phases. The high-level deformations from the pre-to postoperative phase were seen in thin plate spline graphs. The highest deformation was observed at the third ventricle. Third ventricle deformation continued from the early to the late postoperative period, but this deformation is more limited than in preoperative comparisons. CONCLUSION: We demonstrated that shape changes in the third ventricle of patients with pituitary macroadenoma persisted during the postoperative period through statistical geometric morphometric shape analysis. This phenomenon may result from dysfunction of the ventricular surface cilia due to chronic tumor compression and surgery-related neurotrauma. Additionally, we identified the diagnostic limitations of ACA in patients without radiological signs of hydrocephalus.

Exploring the phenotypic features of a large hereditary ataxia cohort: Insights from a single-center experience

Thu, 01 Jan 2026 00:00:00 GMT

Exploring the phenotypic features of a large hereditary ataxia cohort: Insights from a single-center experience Samancı, Bedia; Şahin, Emrah; Atasu, B.; Lohmann, E.; Gökalp, E. Erzurumluoğlu; Artan, S.; Bilgiç, Başar; Hanağası, Haşmet A.; Tüfekçioğlu, Zeynep Meeting Abstract

The anatomical and radiologic relationship of the superior longitudinal system with the middle cerebral artery branches

Thu, 01 Jan 2026 00:00:00 GMT

The anatomical and radiologic relationship of the superior longitudinal system with the middle cerebral artery branches Akyüz, Mehmet E.; Şahin, Mehmet Hakan; Temtek, Ufuk; Gök, Egemen; Keleş, Abdullah; Bozdağ, Selin; Erginoğlu, Ufuk; Kadıoğlu, Hakan H.; Türe, Uğur; Başkaya, Mustafa Kemal Background The superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) connects the temporal and frontal lobes through the parietal region. Although well-studied, the SLF/AF arterial supply and 3D-relationship with the middle cerebral artery (MCA) have not been reported. We examined this using cadaveric fiber dissection and tractography to provide neurosurgical-relevant 3D information.Methods Ten cadaveric hemispheres were removed, vascular tissues cleaned, and fiber dissection performed. In another 10 hemispheres, artery-preserving dissections were carried out in situ. Diffusion Tensor Imaging tractography and Magnetic Resonance Angiography (MRA) of 10 healthy individuals were 3D reconstructed with consistent nomenclature.Results Fiber dissections revealed the superior longitudinal complex (SLF-C), the superior longitudinal fasciculus II (SLF-II), the superior longitudinal fasciculus III (SLF-III), and the arcuate fasciculus (AF) fiber tracts in vascular and meningeal cleared hemispheres. These fiber tracts were also revealed in five heads with intact MCA arterial structures from the MCA bifurcation to the medullary branches. This provided visualization of the SLF/AF and its 3D relationship with the MCA. SLF-C, SLF-II, SLF-III, and AF were shown individually and together with tractography of healthy individuals. The 3D relationship between these fiber tracts, the MCA and its branches was demonstrated by overlaying MRA vascular segmentations onto tractography images.Conclusion This is the first report showing the SLF/AF and MCA relationship as a whole, from its cortical to its medullary branches, by overlaying tractography with MRA reconstructions. This 3D analysis provides valuable insights into their spatial organization to enhance surgical practice and understand the vascular associations of the SLF/AF.