TR-Dizin İndeksli Yayınlar KoleksiyonuTR-Dizin Indexed Publications Collectionhttps://hdl.handle.net/20.500.12900/82024-03-28T12:14:34Z2024-03-28T12:14:34ZEvaluation of Cytotoxicity and Antibacterial Effect of Different Types of Mineral Trioxide AggregateÜnlü, ÖzgeEgil, EdibeDemirci, MehmetKuşoğlu, Sedahttps://hdl.handle.net/20.500.12900/3062024-01-11T09:29:23Z2023-01-01T00:00:00ZEvaluation of Cytotoxicity and Antibacterial Effect of Different Types of Mineral Trioxide Aggregate
Ünlü, Özge; Egil, Edibe; Demirci, Mehmet; Kuşoğlu, Seda
Objective: Mineral trioxide aggregate (MTA) has been used as a filling material in endodontic procedures over decades. The newer formulations of MTA were launched in the dental market and their cytotoxic, proliferative and antimicrobial effects need to be revealed. This study compared the possible cytotoxic and proliferative effects on fibroblasts and the antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, and Enterococcus faecalis of four different MTAs in the dental market. Materials and Methods: Cytotoxicity assay was performed on 3T3 fibroblast cell lines were determined using yellow tetrazolium 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, while the antimicrobial activity was tested with the broth microdilution method. Results: RetroMTA, AngelusMTA, and NeoMTA demonstrated a proliferative effect on 3T3 cells, suggesting induction in tissue repair. Moreover, NeoMTA showed the highest antimicrobial activity against all strains tested. Conclusion: According to our study, NeoMTA and RetroMTA may be recommended for clinical applications in comparison with the conventional AngelusMTA.
2023-01-01T00:00:00ZÇocuklarda Nazofarengeal Streptococcus pneumoniae Taşıyıcılığı ve Penisilin DirenciÖzdemir, Abdurrahman AvarSalman, Nuranhttps://hdl.handle.net/20.500.12900/472021-12-06T14:09:15Z2018-01-01T00:00:00ZÇocuklarda Nazofarengeal Streptococcus pneumoniae Taşıyıcılığı ve Penisilin Direnci
Özdemir, Abdurrahman Avar; Salman, Nuran
Amaç Penisiline dirençli suşların varlığı ve çoklu ilaç direncinin ortaya çıkması pnömokokların neden olduğu enfeksiyonların tedavisini zorlaştırmaktadır. Araştırmamızın amacı sağlıklı çocuklarda Streptococcus pneumoniae taşıyıcılığını ve risk faktörlerini belirlemek, elde edilen suşlarda penisilin direnç oranlarını saptayarak ülkemiz verilerine katkıda bulunmaktır. ( Sakarya Tıp Dergisi 2018, 8(1):7-13 ) Gereç ve Yöntem Çalışmamız Mayıs-Haziran 2001 tarihleri arasında İstanbul Tıp Fakültesi kreş-anaokulunda 175 çocuk üzerinde gerçekleştirildi. Çalışmaya alınan çocuklar pnömokok taşıyıcılığı ve penisilin direnci için risk faktörleri açısından sorgulandı. Pnömokok olduğu tespit edilen suşlarda oksasilin diskleri kullanılarak penisilin direnci, E-test kullanılarak minimal inhibitör konsantrasyon (MIC) belirlendi. Bulgular Çocukların 97’si (%55.7) erkek, 78’i (%44.6) kız idi. Yaş ortalaması 49.4±16.3 ay (Dağılım aralığı; 10-75) olarak bulundu. Alınan boğaz kültürlerinden yapılan ekimlerde 18 (%10.3) çocukta pnömokok taşıyıcılığı saptandı. Taşıyıcı olan ve olmayan çocuklar risk faktörleri açısından incelendiğinde, gruplar arasında risk faktörleri açısından istatistiksel olarak fark bulunmuyordu (p>0.05). S. pneumoniae olarak tespit edilen 18 suş penisilin direnci açısından değerlendirildiğinde 5 tanesi (%27.8) penisiline dirençli diğer 13 (%72.2) suş ise duyarlı bulundu. E-Test yöntemi ile MIC değerleri saptanan dirençli suşlardan 2 tanesinin (%11.1) orta dirençli, 3 (%16.7) tanesinin yüksek dirençli olduğu tespit edildi. Sonuç Çalışmamızda taşıyıcılık oranları bu konuda yapılan çalışmaların bir kısmına göre daha düşük bulunsa da penisilin direnci oranı önceki çalışmalara benzer bulunmuştur.; Objective The presence of resistant strains and the emergence of multiple drug resistance make it difficult to treat infections caused by pneumococci. The aim of this study was to determine the carriage of Streptococcus pneumoniae, risk factors in healthy children and to contribute to national data by determining penicillin resistance rates in the strains obtained. ( Sakarya Med J 2018, 8(1):7-13 ). Materials and Methods Our study was carried out on 175 children in the kindergarten of Istanbul Medical Faculty between May and June 2001. The children participating in the study were questioned for risk factors of pneumococcal carriage and penicillin resistance. Penicillin resistance was determined using oxacillin discs in the pneumococcal strains, and minimal inhibitor concentration (MIC) was determined using E-test. Results The ninety-seven (55.7%) of the children were male and 78 (44.6%) were female. The mean age was 49.4 ± 16.3 months (min-max; 10- 75). Pneumococcal carriage was detected in 18 (10.3%) of the children. There was no statistically significant difference between the groups in terms of risk factors (p> 0,05). When the 18 strains which were identified as S. pneumoniae were evaluated, 5 (27.8%) were resistant to penicillin and 13 (72.2%) were susceptible to penicillin resistance. The MIC values of the resistant strains determined by E-test method; moderate resistance was found in 2 (11.1%) strains and high resistance was 3 (16.7%). Conclusions: Although the rates of carriage in our study are lower than some of the previous studies, the rate of penicillin resistance was found similar to previous studies.
2018-01-01T00:00:00ZAkut Kolesistit Tanısında İnflamasyon Belirteçlerinden Nötrofillenfosit ve Trombosit-lenfosit Oranlarının C-reaktif protein Düzeyine Üstünlüğü Var mı?Gökçe, Feridun SuatGökçe, Aylin Handehttps://hdl.handle.net/20.500.12900/462021-12-06T14:05:56Z2019-01-01T00:00:00ZAkut Kolesistit Tanısında İnflamasyon Belirteçlerinden Nötrofillenfosit ve Trombosit-lenfosit Oranlarının C-reaktif protein Düzeyine Üstünlüğü Var mı?
Gökçe, Feridun Suat; Gökçe, Aylin Hande
Amaç: Akut kolesistit acil servis ve genel cerrahi polikliniklerinde sık tanı alan hastalıklardandır. İnflamasyon derecesi hastalığın morbidite ve mortalitesi üzerine etkilidir. Bu çalışmada inflamasyon derecesini ölçmede; nötrofil-lenfosit oranı, trombosit-lenfosit oranı ve ortalama trombosit hacmi düzeyini klasik inflamasyon belirteçleriyle karşılaştırmak ve hangi değerlerin daha anlamlı olduğunu değerlendirmek istedik. Yöntemler: Kliniğimizde Haziran 2012 ve Aralık 2017 tarihleri arasında yapılan kolesistektomi olguları retrospektif olarak incelendi. Çalışmaya alınan olgular; patoloji sonuçlarına göre akut kolesistit olan olgular grup 1, akut kolesistit olmayan olgular ise grup 2 olarak ayrıldı. Çalışmada gruplar arası yatış süreleri, C-Reaktif Protein (CRP), lökosit değerleri, nötrofil-lenfosit oranı (NLO), trombosit-lenfosit oranı (PLO), kırmızı kan hücre dağılımı (RDW) ve ortalama trombosit hacmi düzeyleri (MPV) karşılaştırıldı. Bulgular: Grup 1 deki olguların hastanede yatış süresi grup 2 ye göre istatistiksel açıdan anlamlı düzeyde daha uzundu (p<0.001). Gruplar arası MPV ve RDW değerleri arasında anlamlı fark saptanmadı (sırasıyla; p=0.128, p=0,707). Grup 1’de NLO, PLO, lökosit ve CRP değerleri grup 2 ye göre istatistiksel olarak anlamlı düzeyde yüksek saptandı ( hepsi; p<0.001). Sonuç: Çalışmamızda, akut kolesistit tanısında RDW ve MPV değerlerini, inflamasyon belirteci olarak anlamlı bulmadık. Akut kolesistitte, inflamasyon derecesini saptamada; NLO ve PLO’ nın rutinde kullanılan tetkikler olan lökosit ve CRP değeri kadar anlamlı olduğu söylenebilir.; Objective: Acute cholecystitis is one of the common conditions encountered in emergency services and general surgery outpatient clinics. Survival and mortality rates positively correlate with the severity of inflammation. In this study, we aimed to compare established markers of inflammation to the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and the mean platelet volume and to assess which were the most clinically relevant. Methods: Patients who underwent cholecystectomy in our clinic between June 2012 and June 2017 were retrospectively reviewed. Study subjects were classified into two groups: Group 1, patients with acute cholecystitis and Group 2, patients without acute cholecystitis. Two groups were compared to each other in the length of hospital stay, CRP concentrations, leukocyte counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), red blood cell distribution width, and the mean platelet volume. Results: The length of hospital stay was significantly longer in the Group 1 compared to the Group 2 (p<0.001). No significant differences were found between the groups in the MPV and RDW (p=0.128 and p=0.707, respectively). The NLR, PLR,leukocyte and C-reactive protein were statistically significantly higher in the Group 1 compared to the Group 2 ( all; p<0.001). Conclusion: Our study failed to demonstrate clinical relevance of RDW and MPV values as inflammation markers. We would like to emphasize that the NLR and PLR may be at least as helpful as other routine tests in determining the severity of inflammation.
2019-01-01T00:00:00ZRecurrent Laryngeal Nerve Palsy After Cervical Spine Surgery Can Be PreventedDoğu, HüseyinCan, Halilhttps://hdl.handle.net/20.500.12900/442023-08-23T07:51:41Z2020-01-01T00:00:00ZRecurrent Laryngeal Nerve Palsy After Cervical Spine Surgery Can Be Prevented
Doğu, Hüseyin; Can, Halil
Objective: To prevent postoperative laryngeal nerve palsy in patients undergoing anterior cervical spine surgery (ACSS). Materials and Methods: A retrospective study was conducted with data from 643 patients who underwent ACSS between 2006 and 2019. Of these patients, 125 who underwent only ACSS served as group I; the other 518, who underwent retractor loosening and displacement along with ACSS, served as group II. The two groups were compared, and paralyzed patients were compared with the general community. In the 518 patients in group II, the Cloward retractor was loosened every 15 minutes, which resulted in a slight change in its position. This protocol was unlike the standard procedure. The retractor was left loose during copy scopy. Results: The majority (58%) of the patients were female, and average age was 47 years (range: 24 to 75 years). The mean duration of surgery was 152 minutes in group I and 162 minutes in group II. Transient laryngeal nerve palsy developed postoperatively in three patients (2.4%) of group I but no patients in group II. No significant difference was observed in terms of surgical level, duration of surgery, age, gender, or comorbid conditions. Conclusion: Retractor loosening and displacement for every 15 minutes during ACSS helps prevent postoperative recurrent laryngeal nerve palsy.
2020-01-01T00:00:00Z