Browsing by Author "Sever, İbrahim Halil"
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Atorvastatin Improves the Propionic Acid- Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action
Durankuş, Ferit; Budak, Korkut; Albayrak, Yakup; Sever, İbrahim Halil; Özkul, Bahattin; Uyanıkgil, Yiğit; Albayrak, Neslihan; Erbaş, Oytun (Cureus Inc, 2023)Amaç Bu çalışmanın amacı, atorvastatinin propiyonik asit kaynaklı otizm modelinde sfingozin-1-fosfat ve antiinflamatuar etkilerini artırarak görüntüleme ve beyin dokusu incelemeleri ile faydalarını araştırmaktır. Malzemeler ... -
Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model
Özkul, Bahattin; Urfalı, Furkan Ertürk; Sever, İbrahim Halil; Bozkurt, Mehmet Fatih; Sogut, Ibrahim; Elgörmüş, Çağrı Serdar; Erbaş, Oytun (Taylor & Francis Ltd, 2022)Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil in the ASD rat model induced by propionic acid ... -
Medroxyprogesterone acetate improves propionic acid-induced autism rat model and magnetic resonance spectroscopic correlation
Bozkurt, Mehmet Fatih; Bhayal, Muhammad Nasir; Sever, İbrahim Halil; Özkul, Bahattin; Erbaş, Oytun (Bangladesh Pharmacological Society, 2022)The protective effect of medroxyprogesterone acetate on propionic acid induced autism in rats was evaluated. For this purpose, 30 rats were divided into three groups. The significant difference in the levels of IL-17 ... -
Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
Erdoğan, Mümin Alper; Turk, Miray; Doganay, Gizem Dinler; Sever, İbrahim Halil; Özkul, Bahattin; Söğüt, İbrahim; Eroğlu, Ebru; Uyanikgil, Yigit; Erbaş, Oytun (Springer, 2023)Recent research on placental, embryo, and brain organoids suggests that the COVID-19 virus may potentially affect embryonic organs, including the brain. Given the established link between SARS-CoV-2 spike protein and ... -
Reparative, Neuroprotective and Anti-Neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Model
Gürkan, Gökhan; Atasoy, Özüm; Cini, Nilsu; Sever, İbrahim Halil; Özkul, Bahattin; Yaprak, Gökhan; Şirin, Cansın; Uyanıkgil, Yiğit; Kızmazoğlu, Ceren; Erdoğan, Mumin Alper; Erbaş, Oytun (KOREAN NEUROSURGICAL SOC, 2023)Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte ... -
Short term protective effect of digitoxin in sepsis-induced acute lung injury
Bora, Ejder Saylav; Erdoğan, Mümin Alper; Özkul, Bahattin; Sever, İbrahim Halil; Söğüt, İbrahim; Hürdağ, Canan; Erbaş, Oytun (Tech Science Press, 2022)Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect ...