Browsing by Author "Gelişgen, Remise"
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Can circulating oxidative stress-related biomarkers be used as an early prognostic marker for COVID-19?
Uysal, Pelin; Yüksel, Arzu; Durmuş, Sinem; Cuhadaroglu, Cağlar; Gelişgen, Remise; Uzun, Hafize (Frontiers Media Sa, 2023)Arka Plan Oksidatif stres birçok hastalığın patogenezinde önemli bir rol oynar. Bu çalışma, yeni COVİD-19 hastalarında nükleer faktör kappa B (NF-kappa B) ile oksidatif stres arasındaki ilişkiyi ve hastalığın ciddiyetini ... -
Diagnostic utility and discriminative ability of cholesterol-modified prognostic nutritional index and inflammatory indicators in colorectal cancer: a retrospective case-control study
Papila, Berrin; Durmuş, Sinem; Guliyev, Murad; Alan, Özkan; Demirci, Nebi Serkan; Gelişgen, Remise; Papila, Çiğdem; Uzun, Hafize (NATURE PORTFOLIO, 2026)Malnutrition and altered biochemical parameters are common in colorectal cancer (CRC) patients. This study aimed to evaluate the diagnostic utility and discriminative ability of nutritional indices, including cholesterol-modified ... -
Diagnostic Value of Serum and Salivary Podoplanin as Clinical Biomarkers for Distinguishing Oral Cancer from Oral Leukoplakia
Uzun, Hafize; Bozarslan, Güven; Dumur, Şeyma; Mısırlıoğlu, Naile Fevziye; Elgörmüş, Mehmet Nuri; Duvarcı, Canan; Gelişgen, Remise; Karaaltın, Ayşegül Batıoğlu; Yılmaz, Yetkin Zeki (MDPI, 2026)Objective: This study aimed to evaluate serum and salivary podoplanin (PDPN) levels in patients with oral cancer (OC) and oral leukoplakia (OL) and to investigate their potential role as diagnostic biomarkers in distinguishing ... -
Dysfunction of PTEN-Associated MicroRNA Regulation: Exploring Potential Pathological Links in Type 1 Diabetes Mellitus
Şenyiğit, Abdulhalim; Durmuş, Sinem; Oruç, Aykut; Gelişgen, Remise; Uzun, Hafize; Tabak, Ömür (MDPI, 2024)Background and Objectives: Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease with T cell-mediated pathogenesis of pancreatic β-cell destruction, leading to insulin deficiency. MicroRNAs such as miR-223 and miR-106b, ... -
Dysfunction of PTEN-Associated MicroRNA Regulation: Exploring Potential Pathological Links in Type 1 Diabetes Mellitus
Şenyiğit, Abdulhalim; Durmuş, Sinem; Oruç, Aykut; Gelişgen, Remise; Uzun, Hafize; Tabak, Ömür (MDPI, 2024)Background and Objectives: Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease with T cell-mediated pathogenesis of pancreatic beta-cell destruction, leading to insulin deficiency. MicroRNAs such as miR-223 and miR-106b, ... -
The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease
Gökçe, Aylin Hande; Gökçe, Feridun Suat; Durmuş, Sinem; Hajiyeva, Ramila; Ersöz, Feyzullah; Gelişgen, Remise; Uzun, Hafize (Assoc Medica Brasileira, 2020)AIM: The aim of this study was to examine the roles of nitric oxide (NOx), endothelial nitric oxide synthetase (eNOS), and asymmetric dimethylarginine (ADMA), which is the major endogenous inhibitor of nitric oxide synthases ... -
Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy
Doğan, Zeki; Ergun, D. D.; Durmus, S.; Şahin, Hilal; Şentürk, G. E.; Gelişgen, Remise; Senyigit, A.; Uzun, Hafize (Verduci Publisher, 2023)Objective: Oxidative stress and hypoxia play an important role in the pathogenesis of various cardiovascular diseases. We aimed to evaluate the effectiveness of sacubitril/valsartan (S/V) and Empagliflozin (EMPA) on ... -
Epigenetic and Inflammatory Signatures in Familial Mediterranean Fever: Implication of miR-204-3p and miR-223-3p in Pyrin-Mediated Immune Regulation
Hajiyeva, Ramila; Durmuş, Sinem; Çakatay, Ufuk; Demirbaş, Kaan Can; Şahin, Sezgin; Adrovic, Amra; Gelişgen, Remise; Kasapçopur, Özgür; Uzun, Hafize (MDPI, 2026)Objectives: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by MEFV mutations, leading to recurrent fever and inflammation. Dysregulation of innate and adaptive immunity, including altered expression ... -
Interplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus
Durmuş, Sinem; Şahin, Sezgin; Adrovic, Amra; Barut, Kenan; Gelişgen, Remise; Uzun, Hafize; Kasapçopur, Özgür (BMJ PUBLISHING GROUP, 2025)Objective Juvenile SLE (jSLE) is an autoimmune disease characterised by the presence of high levels of autoantibodies, predominantly targeting nuclear antigens, resulting in a breakdown of self-tolerance. However, its ... -
Liraglutide Enhances Cell Viability and Reduces Oxidative Stress in Hyperglycemic H9c2 Cardiomyocytes
Durmuş, Sinem; Doğan, Zeki; Ergün, Dilek Düzgün; Özdemir, Mahmut; Şahin, Hakan; Şentürk, Gözde Erkanlı; Gelişgen, Remise; Uzun, Hafize (MDPI, 2025)Background and Objectives: Cardiovascular disease remains a leading cause of mortality in Diabetes mellitus (DM), where chronic hyperglycemia induces oxidative stress, mitochondrial dysfunction, and hypoxia in cardiomyocytes. ... -
Maternal serum preptin levels in the pathogenesis and diagnosis of gestational diabetes mellitus
Kıraç Utku, İrem; Demir, Esra; Özkan, Hanişe; Sahtiyancı, Berrak; Uzun, Hafize; Ekinci, İskender; Büyükkaba, Mitat; Durmuş, Sinem; Akarsu, Murat; Gelişgen, Remise; Tabak, Ömür (Society of Medical Biochemists of Serbia, 2023)Background: Gestational diabetes mellitus (GDM) is a metabolic disorder that occurs during pregnancy that increases both maternal and fetal mortality and morbidity. It was investigated whether there is a change in circulating ... -
miR-21 and cathepsin B in familial Mediterranean fever: novel findings regarding their impact on disease severity
Durmuş, Sinem; Gelişgen, Remise; Hajiyeva, Ramila; Adrovic, Amra; Yıldız, Mehmet; Yücesan, Emrah; Barut, Kenan; Kasapçopur, Özgür; Uzun, Hafize (BMJ PUBLISHING GROUP, 2025)Objective The limited predictive effect of genotype on familial Mediterranean fever (FMF) phenotype suggests that epigenetic factors and alternative mechanisms that may cause IL-1 beta release could contribute to phenotypic ... -
Oxidative Stress and Asprosin Levels in Type 2 Diabetic Patients with Good and Poor Glycemic Control
Şenyiğit, Abdulhalim; Durmuş, Sinem; Gelişgen, Remise; Uzun, Hafize (MDPI, 2024)Objectives: HbA1c is the most widely used test as an indicator of glucoregulation in patients with type 2 diabetes mellitus (T2DM). Asprosin and oxidative stress levels can be reduced with good glycemic control (GC) and ... -
Prediction of Preterm Delivery Using Serum Ischemia Modified Albumin, Biglycan, and Decorin Levels in Women with Threatened Preterm Labor
Bıyık, İsmail; Soysal, Cenk; İnce, Özlem Ulaş Onur; Durmuş, Sinem; Öztaş, Efser; Keskin, Nadi; Işıklar, Özben Özden; Karaağaç, Oğuz Han; Gelişgen, Remise; Uzun, Hafize (Georg Thieme Verlag KG, 2023)Objective The serum ischemia modified albumin (IMA), biglycan, and decorin levels of pregnant women who were hospitalized for threatened preterm labor were measured.Methods Fifty-one consecutive pregnant women with a single ... -
Ranolazine exhibits anti-inflammatory and antioxidant activities in H9c2 cardiomyocytes
Doğan, Zeki; Durmus, S.; Ergun, D. D.; Gelişgen, Remise; Uzun, Hafize (Verduci Publisher, 2023)OBJECTIVE: The aim of this study was to evaluate the effectiveness of ranola-zine on hypoxia-inducible factor-1 alpha (HIF-1 alpha) and oxidative stress in H9c2 cardiomyocyte cells.MATERIALS AND METHODS: We have as-sessed ... -
The relationship between oxLDL, sLOX-1, PCSK9 and carotid intima-media thickness in patients with prediabetes and type 2 diabetes
Doğan, Zeki; Şenyiğit, Abdülhalim; Durmuş, Sinem; Duvarcı, Canan; Gelişgen, Remise; Uzun, Hafize; Tabak, Ömür (NATURE PORTFOLIO, 2025)Affection of vascular structures is a known complication in diabetes and prediabetes. Subclinical atherosclerosis begins to develop years before both cardiovascular and cerebrovascular diseases become symptomatic. The aim ... -
Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD
Uysal, Pelin; Teksöz, Duygu; Aksan, Hülya; Durmuş, Sinem; Gelişgen, Remise; Şimşek, Gönül; Uzun, Hafize (Lippincott Williams & Wilkins, 2022)Our aim in this study was to evaluate the prognostic significance of sialic acid (SA) and prolidase activity and to evaluate the association between airflow obstruction severity and these parameters in chronic obstructive ... -
Serum and intestinal tissue zonulin levels in the evaluation of intestinal permeability in rats with acute pancreatitis
Yıldız, Abdullah; Kundaktepe, Berrin Papila; Yüksekdağ, Sema; Durmuş, Sinem; Silav, Zuhal Kuş; Gelişgen, Remise; Ünal, Ethem; Uzun, Hafize (2022)To evaluate the eff ects on malondialdehyde (MDA), superoxide dismutase (SOD), lipid hydroperoxide (LOOH), glutathione (GSH) levels as oxidative stress markers, zonulin levels, and histopathological findings of experimental ... -
Significance of Cyclooxgenase-2 gene polymorphism and related miRNAs in pulmonary arterial hypertension
Durmuş, Sinem; Atahan, Ersan; Avcı Kılıçkıran, Burçak; Önal, Burak; Çakatay, Ufuk; Gelişgen, Remise; Uzun, Hafize (Elsevier, 2022)Background: Pulmonary arterial hypertension (PAH) is a rare disease with a poor prognosis. The suppression of cyclooxygenase-2 (COX-2) expression has been known to impair vascular function in endothelial cells; however, ... -
Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity
Fazlıoğlu, Nevin; Uysal, Pelin; Durmuş, Sinem; Yurt, Sibel; Gelişgen, Remise; Uzun, Hafize (MDPI, 2023)Objective: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that is caused by the reduction or cessation of airflow in the upper airway. Irisin, retinol-binding protein-4 (RBP-4), and adiponectin are the ...
