Browsing by Author "Dümür, Şeyma"
Now showing items 1-20 of 24
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Association of Helicobacter pylori with Serum HIF-1α, HIF-2α, and Human Transmembrane Prolyl 4-Hydroxylase Activity in Patients with Chronic Gastritis
Ergün, Sefa; Kutluk, Fadime; Turgut, Başar Can; Sayılı, Uğurcan; Ergün, Dilek Düzgün; Uzun, Hafize; Dümür, Şeyma (MDPI, 2025)Background and Objectives: Chronic mucosal infection with Helicobacter pylori (H. pylori) plays a key role in the development of gastroduodenal disorders such as chronic gastritis, peptic ulcers, gastric lymphoma, and ... -
Circulating biomarkers associated with pyroptosis in the differential diagnosis of ST-segment elevation and non-ST-segment elevation myocardial infarction
Doğan, Zeki; Şenyiğit, Abdülhalim; Dümür, Şeyma; Mısırlıoğlu, Naile Fevziye; Uzun, Nedim; Aydın, Sümeyye Nur; Melekoğlu, Adem; Altınbilek, Ertuğrul; Çakatay, Ufuk; Uzun, Hafize (FRONTIERS MEDIA SA, 2025)Objectives To evaluate the biomarker value of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3), gasdermin D (GSDMD), caspase-1, interleukin 1 beta (IL-1 beta), and IL-18 in the systemic circulation in ST-elevation ... -
CLINICAL SIGNIFICANCE OF SERUM SYNAPTOPHYSIN-LIKE 1 PROTEIN LEVELS IN BREAST CANCER
Kösem, Yağmur Özge Turaç; Uzun, Hafize; Velidedeoğlu, Mehmet; Kocael, Pınar; Dümür, Şeyma; Şimşek, Osman (SOC MEDICAL BIOCHEMISTS SERBIA, 2024)Background: Mammography, used for breast cancer (BC) screening, has limitations such as decreased sensitivity in dense breasts. Currently used tumor markers are insufficient in diagnosing breast cancer. In this study, we ... -
Diagnostic Utility of Serum Activating Transcription Factor 4 and Toll-like Receptor 4 as Early Biomarkers of Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease
Yalçınkaya, İsa; Ekinci, İskender; Dümür, Şeyma; Duran, Eda Nur; Uzun, Hafize; Yalçınkaya, Melda; Yeniyurt, Elif Kadıoğlu; Alpaydın, Ömer Vehbi; Anataca, Gülden; Tabak, Ömür (MDPI, 2026)Background/Objectives: This study aimed to evaluate the serum activating transcription factor 4 (ATF4) and toll-like receptor 4 (TLR4) levels in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), ... -
Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
Uzun, Nedim; Gündoğar, Özgecan; Mısırlıoğlu, Naile; Yıldırım, Emine; Şahin, Neslin; Dümür, Şeyma; Uzun, Hafize (DE GRUYTER POLAND SP Z O O, 2025)Objectives Accurate diagnosis of acute cholecystitis (AC) is critical because early laparoscopic cholecystectomy significantly reduces complications and mortality. This study evaluates the predictive value of inflammatory ... -
Diagnostic Value of NO-Related Biomarkers (ADMA, NO, eNOS) in Stable COPD and Acute Exacerbation of COPD
El Jundi, Osman; Fenercioğlu, Ayşen Kutan; Uysal, Pelin; Dümür, Şeyma; Cücü, Oğuzhan; Uzun, Hafize (MDPI, 2025)Background: Nitric oxide (NO)-related biomarkers, including asymmetric dimethylarginine (ADMA), nitric oxide (NO), and endothelial nitric oxide synthase (eNOS), may play a role in the pathophysiology and clinical progression ... -
Effect of intratympanic N-acetylcystein (NAC) on vestibulotoxicity model formed with intratympanic gentamicin in Guinea pigs
Babayiğit, Zehra; Yiğider, Ayşe Pelin; Yiğit, Özgür; Algün Gedik, Arzu; Dümür, Şeyma; Uzun, Hafize (TAYLOR & FRANCIS LTD, 2026)BackgroundN-acetylcysteine (NAC) can protect against this damage.AimTo evaluate the effect of intratympanic NAC on the vestibulotoxicity model formed with intratympanic gentamicine in guinea pigs.DesignExperimental Animal ... -
The Effects of L-Ascorbic Acid on Isoniazid-Induced Protein Oxidation and Hepatotoxicity in Rats
Genç, Habibe; Dümür, Şeyma; Ergül, Yakup; Elgörmüş, Yusuf; Uzun, Hafize (İstanbul Atlas Üniversitesi, 2024)Isoniazid (INH) is hepatotoxic drug. Oxidative stress has been reported as one of the mechanisms of INH induced hepatotoxicity. In the current study, our aim was to evaluate the redox status of plasma and liver proteins ... -
The Epidemiology of Deficiency of Vitamin B12 in Preschool Children in Turkey
Elgörmüş, Yusuf; Okuyan, Ömer; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize (MDPI, 2023)Background: Vitamin B12 is a water-soluble vitamin with important cellular functions; it is an essential vitamin. The aim of this study is to determine the B12 levels of children in the period from the 6th month when ... -
Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice
Okuyan, Ömer; Dümür, Şeyma; Elgörmüş, Neval; Uzun, Hafize (MDPI, 2024)Background and Objectives: To evaluate the clinical findings of glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiency in prolonged jaundice and to determine whether the systemic immune inflammation ... -
Evaluation of new generation systemic immune-inflammation markers to predict urine culture growth in urinary tract infection in children
Elgörmüş, Yusuf; Okuyan, Ömer; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize (FRONTIERS MEDIA SA, 2023)ObjectiveSystemic inflammation has been implicated in the development and progression of urinary tract infection (UTI). Accordingly, the aim of this study is to determine whether the white blood cell (WBC), C-reactive ... -
Evaluation of the relationship between monocyte to high-density lipoprotein cholesterol ratio and thrombus burden in patients with deep vein thrombosis
Doğan, Zeki; Bektaşoğlu, Gökhan; Dümür, Şeyma; Uzun, Hafize; Erden, İsmail; Yurtdaş, Mustafa (Revista da Associacao Medica Brasileira, 2023)Bu çalışmanın amacı, derin ven trombozlu hastalarda monosit sayısı ve yüksek yoğunluklu lipoprotein kolesterol düzeylerini ve oranlarını (monosit/yüksek yoğunluklu lipoprotein oranı) değerlendirmek ve tanı anında bu oranın ... -
General Anesthesia or Spinal Anesthesia and Serum Endocan Release After Surgery: A Prospective Observational Study
Gündüz, Ergun; Durmuş, Sinem; Mısırlıoğlu, Naile Fevziye; Cücü, Oğuzhan; Dümür, Şeyma; Dündar, Bağnu; Uzun, Hafize (MDPI, 2025)Background/Objectives: Awake procedures performed under spinal anesthesia (SA) have been associated with reduced hospitalization, costs, and postoperative complications compared with general anesthesia (GA). Endocan, an ... -
The Importance of Serum Perilipin-2 Level as an Early Indicator of Inflammation in Non-Alcoholic Fatty Liver Disease
Alpaydın, Ömer Vehbi; Duran, Eda Nur; Hür, Alpaydın Ayşe; Hür Alpaydın, Ayşe; Ekinci, İskender; Dümür, Şeyma; Uzun, Hafize; Akarsu, Murat; Yalçınkaya, İsa; Tabak, Ömür (MDPI, 2026)Background/Objectives: Non-alcoholic fatty liver disease (NAFLD), also referred to as metabolic dysfunction-associated fatty liver disease (MAFLD), is the most common chronic liver disease, closely associated with obesity ... -
Investigation of the relationship between carotid intima-media thickness and angiopoietin-like factor 3 levels in metabolic dysfunction-associated steatotic liver disease
Yeniyurt, Elif Kadıoğlu; Duran, Eda Nur; Dümür, Şeyma; Ekinci, İskender; Yalçınkaya, İsa; Üstüner, Müge; Çarpan, Hüseyin Emre; Anataca, Gülden; Akarsu, Murat; Topal, Ümmihan (NATURE PORTFOLIO, 2026)Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a common condition characterized by excessive fat accumulation in the liver and is closely ... -
Neurochemical Changes Following Botulinum Toxin Type A in Chronic Migraine: An LC-MS/MS and HPLC Evaluation of Plasma and Urinary Biomarkers
Dümür, Şeyma; Aygün, Demet; Gorica, Era; Boyacı, Hafize; Dündar, Bağnu; Konukoğlu, Dildar; Uzun, Hafize (MDPI, 2026)Background: Botulinum toxin type A (BoNT-A) is an established preventive therapy for chronic migraine (CM), yet the accompanying neurochemical changes remain incompletely characterized. Objective: To evaluate the effects ... -
New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
Okuyan, Ömer; Elgörmüş, Yusuf; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize (MDPI, 2023)Aim: This study evaluated the relationship between the systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) with clinical findings of respiratory syncytial ... -
The Relationship between Vitamin D, Inflammatory Markers, and Insulin Resistance in Children
Okuyan, Ömer; Dümür, Şeyma; Elgörmüş, Neval; Uzun, Hafize (MDPI, 2024)Objective: In this study, we investigated 25-hydroxyvitamin D (25(OH)D, vitamin D), inflammatory hematologic ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation ... -
The Role of Resolvin D1 in the Differential Diagnosis of Pancreatic Ductal Adenocarcinoma and Acute Pancreatitis: A Case-Control Study
Pekmezci, Yasemin; Ergün, Sefa; Turgut, Başar Can; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize; Pekmezci, Salih; Velidedeoğlu, Mehmet (MDPI, 2025)Background and Objectives: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by a dense desmoplastic stroma with a poor prognosis. The aim of this study was to investigate whether resolvin ... -
The role of S100A12 and Toll-like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis
Adrovic, Amra; Barut, Kenan; Kasapçopur, Özgür; Kucur, Mine; Dümür, Şeyma (Wiley Online Library, 2022)Objective Our aim was to investigate the possible relationship between the serum S100A12 and Toll-like receptor 4 (TLR4) levels, and the activity of familial Mediterranean fever (FMF) and juvenile idiopathic arthritis (JIA) ...
