Yazar "Özkul, Bahattin" için listeleme
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Assessment of Apparent Diffusion Coefficient Parameters and Coefficient of Variance in Discrimination of Receptor Status and Molecular Subtypes of Breast Cancer
Özkul, Özlem; Sever, İbrahim; Özkul, Bahattin (Bentham Scıence Publ LTD, 2024)Abstract: Objective: The objective of this study was to investigate the diagnostic power of apparent diffusion coefficient/coefficient of variance (ADCcV) as well as ADC parameters formed based on magnetic resonance ... -
Atorvastatin Improves the Propionic Acid- Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action
Durankuş, Ferit; Budak, Korkut; Albayrak, Yakup; Sever, İbrahim Halil; Özkul, Bahattin; Uyanıkgil, Yiğit; Albayrak, Neslihan; Erbaş, Oytun (Cureus Inc, 2023)Amaç Bu çalışmanın amacı, atorvastatinin propiyonik asit kaynaklı otizm modelinde sfingozin-1-fosfat ve antiinflamatuar etkilerini artırarak görüntüleme ve beyin dokusu incelemeleri ile faydalarını araştırmaktır. Malzemeler ... -
Craniospinal MRI findings in spina bifida patients following fetoscopic, open and postnatal repair
Ay, Larisa A.; Özkul, Bahattin; Alataş, İbrahim; Uğurlar, Doğa; Gür Özcan, Seray G.; Alizada, Orkhan; Özel, Şeyhmus K. (EDIZIONI MINERVA MEDICA, 2023)BACKGROUND: Prenatal spina bifida repair and its clinical outcome are increasingly seen as topics of research even though early postnatal repair is routinely recommended for the treatment of spina bifida. The aim of this ... -
Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model
Özkul, Bahattin; Urfalı, Furkan Ertürk; Sever, İbrahim Halil; Bozkurt, Mehmet Fatih; Sogut, Ibrahim; Elgörmüş, Çağrı Serdar; Erbaş, Oytun (Taylor & Francis Ltd, 2022)Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil in the ASD rat model induced by propionic acid ... -
Indirect evaluation of amyloid deposition by ultrasonography and its relationship with MEFV gene mutation in FMF patients
Urfalı, Mine; Yılmaz, Gürkan; Özkul, Bahattin; Urfalı, Furkan Ertürk (Wiley Online Library, 2022)ObjectiveThe most significant complication in familial mediterranean fever (FMF) patients is dysfunction and organ failure developing depending on amyloid deposition in organs. The golden standard for showing amyloid ... -
Medroxyprogesterone acetate improves propionic acid-induced autism rat model and magnetic resonance spectroscopic correlation
Bozkurt, Mehmet Fatih; Bhayal, Muhammad Nasir; Sever, İbrahim Halil; Özkul, Bahattin; Erbaş, Oytun (Bangladesh Pharmacological Society, 2022)The protective effect of medroxyprogesterone acetate on propionic acid induced autism in rats was evaluated. For this purpose, 30 rats were divided into three groups. The significant difference in the levels of IL-17 ... -
Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation
Bağcıoğlu, Erman; Solmaz, Volkan; Erbaş, Oytun; Özkul, Bahattin; Çakar, Burak; Uyanıkgil, Yiğit; Söğüt, İbrahim (SPRINGER, 2023)To evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic acid (PPA). Thirty male Wistar rats were used in the study, divided into 3 ... -
Neuroprotective effect of polyethylene Glycol (PEG-3350) on radiation-induced brain injury via membrane stabilization
Sever, I. H.; Özkul, Bahattin; Atasoy, Özüm; Cini, Nilsu; Bozkurt, Mehmet Fatih; Erdogan, M. A.; Yaprak, G; Erbaş, Oytun (IJRR - International Journal of Radiation Research, 2023)Background: This research aims to evaluate whether polyethylene glycol (PEG), which can immediately repair neuronal membranes, will have a protective effect against radiation-induced brain injury (RIBI). Materials and ... -
Predicting the Overall Survival in Patients with Advanced Pancreatic Cancer by Calculating L3 Skeletal Muscle Index Derived from CT
Özkul, Bahattin; Ozkul, Ozlem; Bilir, Cemil (Bentham Scıence Publ LTD, 2022)Background: Pancreatic cancer is mostly diagnosed in advanced stages, and treatment results are not satisfactory. L3 skeletal muscle index (SMI) has emerged as a prognostic factor in pancreatic cancer patients. We aimed ... -
Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
Erdoğan, Mümin Alper; Turk, Miray; Doganay, Gizem Dinler; Sever, İbrahim Halil; Özkul, Bahattin; Söğüt, İbrahim; Eroğlu, Ebru; Uyanikgil, Yigit; Erbaş, Oytun (Springer, 2023)Recent research on placental, embryo, and brain organoids suggests that the COVID-19 virus may potentially affect embryonic organs, including the brain. Given the established link between SARS-CoV-2 spike protein and ... -
Protective effect of oxytocin through its anti-inflammatory and antioxidant role in a model of sepsis-induced acute lung injury: Demonstrated by CT and histological findings
Sever, I. H.; Özkul, Bahattin; Erisik Tanriover, D.; Ozkul, O.; Elgörmüş, Çağrı Serdar; Gur, S. G.; Sogut, I. (Taylor & Francis Inc, 2021)Purpose: Although several studies demonstrate the anti-inflammatory effect of oxytocin in different pathophysiological processes, there are limited data describing the impact of oxytocin on acute respiratory distress ... -
Protective Effects of Ibudilast Against Cisplatin-Induced Hepatotoxicity and Nephrotoxicity Mediated by Prostacyclin Enhancement
Özkul, Özlem; Özkul, Bahattin; Erdoğan, Mümin Alper; Erbaş, Oytun (Asian Network for Scientific Information (ANSInet), 2023)Background and Objective: Cisplatin, a prevalent chemotherapy drug, presents hepatotoxic and nephrotoxic side effects, this study explores ibudilast's potential protective effects against such damage via prostacyclin ... -
Quantitative Evaluation of Lung Parenchyma Changes after Treatment in COVID-19 Pneumonia with Volumetric Study in Computed Tomography
Özkul, Bahattin; Urfalı, Furkan Ertürk; Asil, Kıyasettin (Clinical and Experimental Health Sciences, 2022)Objective COVID-19 pandemic, causing approximately 3 million deaths over worldwide, still continues. Effect of COVID-19 pneumonia after treatment on the lungs still not know. Although widely using computed tomography (CT) ... -
Reparative, Neuroprotective and Anti-Neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Model
Gürkan, Gökhan; Atasoy, Özüm; Cini, Nilsu; Sever, İbrahim Halil; Özkul, Bahattin; Yaprak, Gökhan; Şirin, Cansın; Uyanıkgil, Yiğit; Kızmazoğlu, Ceren; Erdoğan, Mumin Alper; Erbaş, Oytun (KOREAN NEUROSURGICAL SOC, 2023)Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte ... -
Short term protective effect of digitoxin in sepsis-induced acute lung injury
Bora, Ejder Saylav; Erdoğan, Mümin Alper; Özkul, Bahattin; Sever, İbrahim Halil; Söğüt, İbrahim; Hürdağ, Canan; Erbaş, Oytun (Tech Science Press, 2022)Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect ... -
Therapeutic effect of finasteride through its antiandrogenic and antioxidant role in a propionic acid-induced autism model: Demonstrated by behavioral tests, histological findings and MR spectroscopy
Sever, I. H.; Özkul, Bahattin; Bozkurt, Mehmet Fatih; Erbaş, Oytun (ELSEVIER IRELAND LTD, 2022)Background: Autism is a clinically defined neurodevelopmental disorder with unknown origin characterized by significant social, communication and behavioral challenges. Although it can be a lifelong condition, treatments ...
