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dc.contributor.authorErdemir, Gökçe
dc.contributor.authorDanışman-Kalındemirtaş, Ferdane
dc.contributor.authorKariper, Ishak Afşin
dc.contributor.authorKuruca, Dürdane Serap
dc.contributor.authorÖzerken, Dilşad
dc.date.accessioned2024-04-18T13:27:56Z
dc.date.available2024-04-18T13:27:56Z
dc.date.issued2023en_US
dc.identifier.citationErdemir, G., Danişman-Kalindemirtaş, F., Kariper, İ. A., Kuruca, D. S., & Özerkan, D. (2023). Comparison of Selenic Acid and Pyruvic Acid-Loaded Silver Nanocarriers Impact on Colorectal Cancer Viability. Journal of fluorescence, 10.1007/s10895-023-03339-4. Advance online publication. https://doi.org/10.1007/s10895-023-03339-4en_US
dc.identifier.issn1573-4994
dc.identifier.urihttps://hdl.handle.net/20.500.12900/363
dc.description.abstractColorectal cancer (CRC) is a leading cause of morbidity and death worldwide. As current cancer drugs are ineffective, new solutions are being sought in other fields, including nanoscience. Similarly, silver nanoparticles play an important role in the pharmaceutical industry as they act as anti-cancer agents with less harmful effects and are usually 1 to 100 nm in size. Selenic acid (SA) and pyruvic acid (PA) are involved in various metabolic pathways in cancer. For this reason, we decided to detect their influence on colorectal cancer using silver-based (Ag) nanocarriers. DLS, Zetasizer, SEM and UV-Vis analyses were used to characterize AgSA and AgPA. A UV spectrophotometer was used to analyze the release of the NPs. MTT analyses were used to measure the viability of HCT116 and HUVEC cells, and IC50 values were calculated using GraphPad Prism. The indicated dosage and particle size of AgSA NPs proved to be suitable for cytotoxicity. Moreover, injection of these nanoparticles into non-cancer cells proved safe due to their minimal toxicity. In contrast, the AgPA NPs have no cytotoxicity and induce proliferation of HCT116 cells. Finally, only the synthesised AgSA nanoparticles could be used for advanced cancer therapy, which is both inexpensive and has minimal side effects.en_US
dc.language.isoengen_US
dc.publisherSPRINGER/PLENUM PUBLISHERSen_US
dc.relation.isversionof10.1007/s10895-023-03339-4en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilver nanoparticleen_US
dc.subjectPyruvic aciden_US
dc.subjectSelenic aciden_US
dc.subjectCytotoxicityen_US
dc.subjectColorectal canceren_US
dc.titleComparison of Selenic Acid and Pyruvic Acid-Loaded Silver Nanocarriers Impact on Colorectal Cancer Viabilityen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorKuruca, Dürdane Serap
dc.relation.journalJOURNAL OF FLUORESCENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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