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dc.contributor.authorGürkan, Gökhan
dc.contributor.authorAtasoy, Özüm
dc.contributor.authorCini, Nilsu
dc.contributor.authorSever, İbrahim Halil
dc.contributor.authorÖzkul, Bahattin
dc.contributor.authorYaprak, Gökhan
dc.contributor.authorŞirin, Cansın
dc.contributor.authorUyanıkgil, Yiğit
dc.contributor.authorKızmazoğlu, Ceren
dc.contributor.authorErdoğan, Mumin Alper
dc.contributor.authorErbaş, Oytun
dc.date.accessioned2024-04-17T14:22:24Z
dc.date.available2024-04-17T14:22:24Z
dc.date.issued2023en_US
dc.identifier.citationGürkan, G., Atasoy, Ö., Çini, N., Sever, İ. H., Özkul, B., Yaprak, G., Şirin, C., Uyanıkgil, Y., Kızmazoğlu, C., Erdoğan, M. A., & Erbaş, O. (2023). Reparative, Neuroprotective and Anti-neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Model. Journal of Korean Neurosurgical Society, 66(5), 511–524. https://doi.org/10.3340/jkns.2023.0049en_US
dc.identifier.issneISSN 1598-7876
dc.identifier.urihttps://hdl.handle.net/20.500.12900/353
dc.description.abstractObjective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte colony stimulating factor (G-CSF) treatment. In addition, the effects of G-CSF on brain functions were examined by magnetic resonance (MR) imaging and histopathologically.Methods : This study used 24 female Wistar albino rats. Drug administration (saline or G-CSF) was started at the beginning of the study and continued for 15 days after whole-brain radiotherapy (WBRT). WBRT was given on day 7 of the start of the study. At the end of 15 days, the behavioral tests, including the three-chamber sociability test, open field test, and passive avoidance learning test, were done. After the behavioral test, the animals performed the MR spectroscopy procedure. At the end of the study, cervical dislocation was applied to all animals.Results : G-CSF treatment positively affected the results of the three-chamber sociability test, open-space test and passive avoidance learning test, cornu Ammonis (CA) 1, CA3, and Purkinje neuron counts, and the brain levels of brain-derived neurotrophic factor and postsynaptic density protein-95. However, G-CSF treatment reduced the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde, tumor necrosis factor-alpha, nuclear factor kappa-B, and lactate. In addition, on MR spectroscopy, G-CSF had a reversible effect on brain lactate levels.Conclusion : In this first designed brain irradiation animal model, which evaluated G-CSF effects, we observed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects and had increased neurotrophic factor expression, neuronal counts, and morphology changes. In addition, G-CSF had a proven lactate-lowering effect in MR spectroscopy and brain materials.en_US
dc.language.isoengen_US
dc.publisherKOREAN NEUROSURGICAL SOCen_US
dc.relation.isversionof10.3340/jkns.2023.0049en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnimal modelsen_US
dc.subjectAnxiolyticen_US
dc.subjectBrain injuriesen_US
dc.subjectGranulocyte colony stimulating factoren_US
dc.subjectIrradiationen_US
dc.titleReparative, Neuroprotective and Anti-Neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Modelen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.authoridhttps://orcid.org/0000-0003-3339-8329en_US
dc.contributor.institutionauthorÖzkul, Bahattin
dc.identifier.volume66en_US
dc.identifier.issue5en_US
dc.identifier.startpage511en_US
dc.identifier.endpage524en_US
dc.relation.journalJOURNAL OF KOREAN NEUROSURGICAL SOCIETYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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