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dc.contributor.authorYılmaz, Mehmet
dc.contributor.authorDokuyucu, Recep
dc.date.accessioned2024-04-16T13:12:54Z
dc.date.available2024-04-16T13:12:54Z
dc.date.issued2023en_US
dc.identifier.citationYılmaz, M., & Dokuyucu, R. (2023). Assessment of sensitivity to the anesthesia in a diabetic rat model. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 27(19), 9029-9033. https://doi.org/10.26355/eurrev_202404_35928en_US
dc.identifier.issn1128-3602
dc.identifier.urihttps://hdl.handle.net/20.500.12900/334
dc.description.abstractOBJECTIVE: Diabetes mellitus and glucose regulation are important in decid-ing on surgical intervention in pre-surgical as-sessments. In our study, we aimed to investigate the correlations between the induction time of anesthesia, glucose level, and weight in a dia-betic rat model.MATERIALS AND METHODS: Weight -matched adult male Wistar rats were grouped as control (n=8) and diabetic (n=8). In the latter group, diabetes was induced with a single intra-peritoneal injection of 50 mg/kg streptozotosin. 72 hours after the injection, animals possessing a blood glucose concentration above 300 mg/ kg were considered diabetic. The weights and blood glucose levels were observed for 7 days. In the end, 80 mg/kg ketamine and 12 mg/kg xylazine were administered to both groups, and the induction time of anesthesia was recorded. The success of anesthesia was confirmed with toe pinching by using a clamp. The Student's L- and Pearson's correlation tests were used for statistical analyses.RESULTS: The induction time of anesthesia was significantly reduced in the diabetic group com-pared to the controls (p<0.01). Diabetic animals weighed less than the control group (p<0.01). The correlation analysis in the diabetic group showed that the weight and blood glucose level of animals did not influence the induction time of anesthesia (respectively, p=0.80, r: 0.150; p=0.68, r:-0.300). A negative correlation between blood glucose concentration and weight was found in diabetics (p<0.05, r:-0.828).CONCLUSIONS: The dosage of anesthetic agents is important in the effectiveness of an-esthesia, and surgical complications. Since our results indicate the susceptibility of diabetics to anesthesia, we suggest that the dose of anes-thetics should be finely adjusted considering the presence of diabetes.en_US
dc.language.isoengen_US
dc.publisherVERDUCI PUBLISHERen_US
dc.relation.isversionof10.26355/eurrev_202404_35928en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectŞeker hastalığıen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectAnestezi dozuen_US
dc.subjectAnesthesia doseen_US
dc.subjectİndüksiyonen_US
dc.subjectInductionen_US
dc.titleAssessment of sensitivity to the anesthesia in a diabetic rat modelen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.authoridhttps://orcid.org/0000-0001-6837-3477en_US
dc.contributor.institutionauthorDokuyucu, Recep
dc.identifier.volume27en_US
dc.identifier.issue19en_US
dc.identifier.startpage9029en_US
dc.identifier.endpage9033en_US
dc.relation.journalEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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