Yazar "Uzun, Hafize" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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The Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes
Fenercioglu, Aysen Kutan; Gonen, Mustafa Sait; Uzun, Hafize; Sipahioglu, Nurver Turfaner; Can, Gunay; Tas, Ebru; Kara, Zehra (Mdpi, 2023)In this study, we aimed to reveal the pro-inflammatory effects of serum 25-hydroxyvitamin D3 (Vit D) deficiency and insufficiency in new-onset type 2 diabetes mellitus (T2DM) and prediabetes. We recruited 84 prediabetes ... -
Association between serum irisin concentration and ischemic stroke: From etiology to clinic
Çalık, Mustafa; Şengül, Yıldızhan; Gürkan, Zahide Mail; Hintoglu, Deniz; Mısırlıoğlu, Naile Fevziye; Uzun, Hafize (Society of Medical Biochemists of Serbia, 2022)Background: To investigate the relationship between irisin levels in serum and classification of subtype of acute ischemic stroke, National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Score (mRS) at the ... -
Association Between Serum Irisin Levels and ST-Segment Elevation Myocardial Infarction
Öztürk, Derya; Melekoğlu, Adem; Altınkiler, Ertuğrul; Çalık, Mustafa; Kösem, Arzu; Kilci, Hakan; Mısırlıoğlu, Naile Fevziye; Uzun, Hafize (Dove Medical Press Ltd, 2023)Background: An acute ST-elevation myocardial infarction (STEMI) is a serious cardiovascular condition with a high risk of morbidity and mortality. Irisin is adipomyokine that is associated with various health conditions. ... -
Can circulating oxidative stress-related biomarkers be used as an early prognostic marker for COVID-19?
Uysal, Pelin; Yüksel, Arzu; Durmuş, Sinem; Cuhadaroglu, Cağlar; Gelişgen, Remise; Uzun, Hafize (Frontiers Media Sa, 2023)Arka Plan Oksidatif stres birçok hastalığın patogenezinde önemli bir rol oynar. Bu çalışma, yeni COVİD-19 hastalarında nükleer faktör kappa B (NF-kappa B) ile oksidatif stres arasındaki ilişkiyi ve hastalığın ciddiyetini ... -
CLINICAL SIGNIFICANCE OF SERUM SYNAPTOPHYSIN-LIKE 1 PROTEIN LEVELS IN BREAST CANCER
Kösem, Yağmur Özge Turaç; Uzun, Hafize; Velidedeoğlu, Mehmet; Kocael, Pınar; Dümür, Şeyma; Şimşek, Osman (SOC MEDICAL BIOCHEMISTS SERBIA, 2024)Background: Mammography, used for breast cancer (BC) screening, has limitations such as decreased sensitivity in dense breasts. Currently used tumor markers are insufficient in diagnosing breast cancer. In this study, we ... -
The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease
Gökçe, Aylin Hande; Gökçe, Feridun Suat; Durmuş, Sinem; Hajiyeva, Ramila; Ersöz, Feyzullah; Gelişgen, Remise; Uzun, Hafize (Assoc Medica Brasileira, 2020)AIM: The aim of this study was to examine the roles of nitric oxide (NOx), endothelial nitric oxide synthetase (eNOS), and asymmetric dimethylarginine (ADMA), which is the major endogenous inhibitor of nitric oxide synthases ... -
The Effect of Virus-Specific Vaccination on Laboratory Infection Markers of Children with Acute Rotavirus-Associated Acute Gastroenteritis
Okuyan, Ömer; Elgörmüş, Yusuf; Sayili, Ugurcan; Dumur, Şeyma; Işık, Özlem Erkan; Uzun, Hafize (Mdpi, 2023)Objective: Rotavirus (RV) is one of the most common and important causes of acute gastroenteritis (AGE) in newborns and children worldwide. The aim of this study was to evaluate the effect of the RV vaccine on the natural ... -
Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy
Doğan, Zeki; Ergun, D. D.; Durmus, S.; Şahin, Hilal; Şentürk, G. E.; Gelişgen, Remise; Senyigit, A.; Uzun, Hafize (Verduci Publisher, 2023)Objective: Oxidative stress and hypoxia play an important role in the pathogenesis of various cardiovascular diseases. We aimed to evaluate the effectiveness of sacubitril/valsartan (S/V) and Empagliflozin (EMPA) on ... -
The Epidemiology of Deficiency of Vitamin B12 in Preschool Children in Turkey
Elgörmüş, Yusuf; Okuyan, Ömer; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize (MDPI, 2023)Background: Vitamin B12 is a water-soluble vitamin with important cellular functions; it is an essential vitamin. The aim of this study is to determine the B12 levels of children in the period from the 6th month when ... -
Evaluation of the relationship between monocyte to high-density lipoprotein cholesterol ratio and thrombus burden in patients with deep vein thrombosis
Doğan, Zeki; Bektaşoğlu, Gökhan; Dümür, Şeyma; Uzun, Hafize; Erden, İsmail; Yurtdaş, Mustafa (Revista da Associacao Medica Brasileira, 2023)Bu çalışmanın amacı, derin ven trombozlu hastalarda monosit sayısı ve yüksek yoğunluklu lipoprotein kolesterol düzeylerini ve oranlarını (monosit/yüksek yoğunluklu lipoprotein oranı) değerlendirmek ve tanı anında bu oranın ... -
Impact of Promising Biomarkers on Severity and Outcome of Acute Pulmonary Embolism
Sagcan, Gulseren; Doğan, Zeki; Uzun, Hafize; Cuhadaroglu, Cağlar; Okumuş, Gülfer; Arseven, Orhan (Dove Medical Press Ltd, 2023)Background: Acute pulmonary embolism (APE) is a common clinical condition. Its severity ranges from asymptomatic radiological findings to fatal obstructive shock. The potential circulating biomarkers have been studied to ... -
Maternal serum preptin levels in the pathogenesis and diagnosis of gestational diabetes mellitus
Kıraç Utku, İrem; Demir, Esra; Özkan, Hanişe; Sahtiyancı, Berrak; Uzun, Hafize; Ekinci, İskender; Büyükkaba, Mitat; Durmuş, Sinem; Akarsu, Murat; Gelişgen, Remise; Tabak, Ömür (Society of Medical Biochemists of Serbia, 2023)Background: Gestational diabetes mellitus (GDM) is a metabolic disorder that occurs during pregnancy that increases both maternal and fetal mortality and morbidity. It was investigated whether there is a change in circulating ... -
New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
Okuyan, Ömer; Elgörmüş, Yusuf; Dümür, Şeyma; Sayılı, Uğurcan; Uzun, Hafize (MDPI, 2023)Aim: This study evaluated the relationship between the systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) with clinical findings of respiratory syncytial ... -
Prediction of Preterm Delivery Using Serum Ischemia Modified Albumin, Biglycan, and Decorin Levels in Women with Threatened Preterm Labor
Bıyık, İsmail; Soysal, Cenk; İnce, Özlem Ulaş Onur; Durmuş, Sinem; Öztaş, Efser; Keskin, Nadi; Işıklar, Özben Özden; Karaağaç, Oğuz Han; Gelişgen, Remise; Uzun, Hafize (Georg Thieme Verlag KG, 2023)Objective The serum ischemia modified albumin (IMA), biglycan, and decorin levels of pregnant women who were hospitalized for threatened preterm labor were measured.Methods Fifty-one consecutive pregnant women with a single ... -
Ranolazine exhibits anti-inflammatory and antioxidant activities in H9c2 cardiomyocytes
Doğan, Zeki; Durmus, S.; Ergun, D. D.; Gelişgen, Remise; Uzun, Hafize (Verduci Publisher, 2023)OBJECTIVE: The aim of this study was to evaluate the effectiveness of ranola-zine on hypoxia-inducible factor-1 alpha (HIF-1 alpha) and oxidative stress in H9c2 cardiomyocyte cells.MATERIALS AND METHODS: We have as-sessed ... -
The relationship between hematological indices as indicators of inflammation and 25-hydroxyvitamin D3 status in newborns
Uzun, Hafize; Elgörmüş, Yusuf; Okuyan, Ömer (National Library of Medicine, 2023)Arka Plan Yenidoğanlarda hematolojik parametreler ile D vitamini durumu arasındaki ilişki hakkında hala pek çok şey bilinmemektedir. Çalışmanın amacı 25(OH)D3 (D vitamini) durumu ile yeni tanımlanmış sistemik inflamatuar ... -
Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD
Uysal, Pelin; Teksöz, Duygu; Aksan, Hülya; Durmuş, Sinem; Gelişgen, Remise; Şimşek, Gönül; Uzun, Hafize (Lippincott Williams & Wilkins, 2022)Our aim in this study was to evaluate the prognostic significance of sialic acid (SA) and prolidase activity and to evaluate the association between airflow obstruction severity and these parameters in chronic obstructive ... -
The Role of Glycogen Synthase Kinase-3β in the Zinc-Mediated Neuroprotective Effect of Metformin in Rats with Glutamate Neurotoxicity
Oruc, Aykut; Oruc, Kadriye Yagmur; Yanar, Karolin; Mengi, Murat; Caglar, Aysel; Kurt, Bahar Öztürk; Altan, Mehmet; Sönmez, Osman Fuat; Cakatay, Ufuk; Uzun, Hafize; Simsek, Gönül (Wiley, 2023)Metformin has been suggested to have protective effects on the central nervous system, but the mechanism is unknown. The similarity between the effects of metformin and the inhibition of glycogen synthase kinase (GSK)-3β ... -
The Role of NF-κB, PPAR-α, and PPAR-γ in Older Adults with Metabolic Syndrome
Demirağ, Filiz; Yavuzer, Serap; Cengiz, Mahir; Yavuzer, Hakan; Kara, Zehra; Ayvacı, Adnan; Avcı, Suna; Yürüyen, Mehmet; Uzun, Hafize; Altıparmak, Mehmet Rıza (Georg Thieme Verlag KG, 2023)The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood yet, and chronic low-grade inflammation is thought to be associated with the development of complications related to MetS. We aimed to investigate ... -
Significance of Cyclooxgenase-2 gene polymorphism and related miRNAs in pulmonary arterial hypertension
Durmuş, Sinem; Atahan, Ersan; Avcı Kılıçkıran, Burçak; Önal, Burak; Çakatay, Ufuk; Gelişgen, Remise; Uzun, Hafize (Elsevier, 2022)Background: Pulmonary arterial hypertension (PAH) is a rare disease with a poor prognosis. The suppression of cyclooxygenase-2 (COX-2) expression has been known to impair vascular function in endothelial cells; however, ...