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dc.contributor.authorKetenci, Sema
dc.contributor.authorDündar, Bağnu
dc.contributor.authorKalaycı, Mustafa Uygar
dc.contributor.authorDuranay, Recep
dc.contributor.authorAynacıoğlu, Ahmet Şükrü
dc.date.accessioned2022-11-05T09:05:48Z
dc.date.available2022-11-05T09:05:48Z
dc.date.issued2022en_US
dc.identifier.citationKetenci, S., Uygar Kalaycı, M., Dündar, B., Duranay, R., & Şükrü Aynacıoğlu, A. (12.08.2022). Elevated serum midkine levels in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. International Immunopharmacology. 110(108939). pp. 1-6. https://doi.org/10.1016/j.intimp.2022.108939 ‌en_US
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.urihttp://www.journals.elsevier.com/international-immunopharmacology/
dc.identifier.urihttps://hdl.handle.net/20.500.12900/88
dc.description.abstractBackground: The coronavirus disease-2019 (COVID-19) pandemic has caused important health, economic, social, and cultural problems worldwide. Recent findings demonstrate an excessive cytokine release during the disease development, especially in the seriously life-threatening form of COVID-19. Among other chemokines and cytokines that are released in high amounts at the infection site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), midkine (MK), which is a potent pro-inflammatory growth factor/ cytokine, can be also overexpressed and contribute to the pathophysiological process in patients infected with SARS-CoV-2. Materials and method: Serum was collected from 87 intensive care unit (ICU) patients that are COVID-19 positive and 50 healthy volunteers in the control group with a negative PCR test and without disease symptoms. Circulating MK concentration was measured by enzyme-linked immunosorbent assay (ELISA). Results: COVID-19 patients had a significantly higher serum MK concentration compared to non-COVID-19 control subjects (1892.8 +/- 1615.8 pg/mL versus 680.7 +/- 907.6 pg/mL, respectively; P < 0.001). The cut-off MK concentration was 716.7 pg/ mL, with the sensitivity and specificity of 75.9 % and 76.0 %, respectively. The area under the receiver operating characteristic (ROC) curve of MK was = 0.827. Our findings showed that circulating MK levels are significantly increased in SARS-CoV-2 infected patients. Conclusion: We suggest that MK is involved in the pathogenesis of COVID-19 and may be a part of hypercytokinaemia. Therefore, MK may serve as a supporting biomarker in the diagnosis of COVID-19, and blocking MK actions or its targets may attenuate the inflammatory process and the severity of the disease.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.intimp.2022.108939en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectMidkineen_US
dc.subjectSerum Levelsen_US
dc.titleElevated serum midkine levels in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patientsen_US
dc.title.alternativeen_US
dc.typearticleen_US
dc.departmentİstanbul Atlas Üniversitesien_US
dc.authoridSema Ketenci / 0000-0002-6695-7003en_US
dc.authoridAhmet Şükrü Aynacıoğlu / 0000-0001-5393-4606en_US
dc.authoridRecep Duranay / 0000-0002-4423-9780en_US
dc.authoridMustafa Uygar Kalaycı / 0000-0002-2215-0072en_US
dc.authoridBağnu Dündar / 0000-0003-1052-5911en_US
dc.contributor.institutionauthorKetenci, Sema
dc.contributor.institutionauthorDündar, Bağnu
dc.contributor.institutionauthorKalaycı, Mustafa Uygar
dc.contributor.institutionauthorDuranay, Recep
dc.contributor.institutionauthorAynacıoğlu, Ahmet Şükrü
dc.identifier.volume110en_US
dc.identifier.issue108939en_US
dc.identifier.startpage1en_US
dc.identifier.endpage6en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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