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dc.contributor.authorOzbeyli, Dilek
dc.contributor.authorGürler, Esra Bihter
dc.contributor.authorBuzcu, Hulya
dc.contributor.authorCilingir-Kaya, Ozlem Tugce
dc.contributor.authorCam, Muhammet Emin
dc.contributor.authorYüksel, Meral
dc.date.accessioned2021-03-31T20:25:28Z
dc.date.available2021-03-31T20:25:28Z
dc.date.issued2020
dc.identifier.issn2148-5607
dc.identifier.urihttps://doi.org/10.5152/tjg.2020.19520
dc.identifier.urihttps://hdl.handle.net/20.500.12900/41
dc.description44th National Physiology Congress of the Turkish-Society-of-Physiological-Sciences - Free Radical Scavenging Activity of Astaxanthin in Experimental Acute Pancreatitis Induced by Serulein -- NOV 01-04, 2018 -- Antalya, TURKEYen_US
dc.descriptionWOS:000592228300005en_US
dc.descriptionPubMed: 33169708en_US
dc.description.abstractBackground/Aims: Astaxanthin (ATX) is a naturally occurring carotenoid and a potent antioxidant. Various anti-inflammatory effects of ATX have been examined. We aimed to investigate the protective effect of ATX and its mechanism in a cerulein-induced acute pancreatitis rat model. Materials and Methods: The rats were randomized into 2 main groups as control (C) and acute pancreatitis group (AP). AP group was subsequently divided into subgroups as AP+vehicle (AP), AP+ATX, and ATX+peroxisome proliferator-activated receptor-alpha antagonist GW6471 (ATX+GW) groups. To induce AP, the rats were administered cerulein (50 mu g/kg, intraperitonally [ip]) at 1 hour intervals, whereas the C group received saline. The AP group was treated with vehicle olive oil, ATX 40 mg/kg/orally, or GW6471 and ATX (GW1 mg/kg/ip; ATX; 40 mg/kg/peroral). Treatments were administered after the 1st cerulein injection. At the 7th hour after the final injection, the rats were killed and the pancreatic tissue was used for the determination of malondialdehyde (MDA), glutathione (GSH), and myeloperoxidase (MPO) activities and luminol-lucigenin chemiluminescence levels. Serum amylase, lipase, and histopathological analyses were performed. Results: Elevated serum lipase and amylase levels in the vehicle-treated AP group (p<0.01) decreased in the ATX and ATX+GW groups (p<0.05). In the AP groups, GSH was reduced and MDA, MPO, luminol, and lucigenin levels were increased (p<0.05-0.001). ATX reversed these changes (p<0.05-0.001). The vehicle-treated group revealed significant severe cytoplasmic degeneration and vacuolization, whereas ATX ameliorated these destructions. GW6471 did not abolish the positive effects of ATX biochemically or histologically. Conclusion: ATX has a potent protective effect on AP via its radical scavenging and antioxidant properties. Therefore, we believe that ATX may have therapeutic potential.en_US
dc.description.sponsorshipTurkish Soc Physiol Scien_US
dc.language.isoengen_US
dc.publisherAvesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPancreatitisen_US
dc.subjectinflammationen_US
dc.subjectastaxanthinen_US
dc.subjectfree radical scavengersen_US
dc.titleAstaxanthin alleviates oxidative damage in acute pancreatitis via direct antioxidant mechanismsen_US
dc.typeconferenceObjecten_US
dc.departmentİstanbul Atlas Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.department-temp[Ozbeyli, Dilek] Marmara Univ, Dept Med Pathol Tech, Vocat Sch Hlth Serv, Istanbul, Turkey; [Gurler, Esra Bihter] Istanbul Atlas Univ, Dept Physiol, Sch Med, Istanbul, Turkey; [Buzcu, Hulya] Univ Hlth Sci, Dept Physiol, Sch Med, Istanbul, Turkey; [Cilingir-Kaya, Ozlem Tugce] Marmara Univ, Dept Histol & Embryol, Sch Med, Istanbul, Turkey; [Cam, Muhammet Emin] Marmara Univ, Dept Pharmacol, Sch Pharm, Istanbul, Turkey; [Cam, Muhammet Emin] UCL, Dept Mech Engn, Torrington Pl, London, England; [Yuksel, Meral] Marmara Univ, Dept Med Lab Tech, Vocat Sch Hlth Serv, Istanbul, Turkeyen_US
dc.contributor.institutionauthorGürler, Esra Bihter
dc.identifier.doi10.5152/tjg.2020.19520
dc.identifier.volume31en_US
dc.identifier.issue10en_US
dc.identifier.startpage706en_US
dc.identifier.endpage712en_US
dc.relation.journalTurkish Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US


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