FakültelerFacultieshttps://hdl.handle.net/20.500.12900/22024-03-28T11:47:00Z2024-03-28T11:47:00ZThe Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and PrediabetesFenercioglu, Aysen KutanGonen, Mustafa SaitUzun, HafizeSipahioglu, Nurver TurfanerCan, GunayTas, EbruKara, Zehrahttps://hdl.handle.net/20.500.12900/3252024-03-08T08:48:33Z2023-01-01T00:00:00ZThe Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes
Fenercioglu, Aysen Kutan; Gonen, Mustafa Sait; Uzun, Hafize; Sipahioglu, Nurver Turfaner; Can, Gunay; Tas, Ebru; Kara, Zehra
In this study, we aimed to reveal the pro-inflammatory effects of serum 25-hydroxyvitamin D3 (Vit D) deficiency and insufficiency in new-onset type 2 diabetes mellitus (T2DM) and prediabetes. We recruited 84 prediabetes patients, 94 new-onset T2DM patients and 113 healthy participants. We measured the levels of C-reactive protein (CRP), fibrinogen, ferritin, interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), nuclear factor kappa-B (NF-kappa B) and mitogen-activated protein kinase (MAPK) in the serum of the participants. ANOVA Bonferroni and Kruskal-Wallis Dunn tests were used to compare the inflammation markers and vitamin D levels between the groups. Based on covariance analysis with age, gender and BMI, the Vit D levels of the T2DM group were significantly lower (p < 0.003). Pro-inflammatory markers and CRP were significantly higher in prediabetic and diabetic subjects. In the prediabetes group, IL-1 beta, IL-6, IL-8, TNF-alpha and MAPK were significantly higher in those with Vit D insufficiency and deficiency groups. In the T2DM group, IL-1 beta, IL-6, IL-8, TNF-alpha, NF-kappa B, MAPK and CRP were significantly higher in those with Vit D insufficiency and deficiency. Our study emphasizes the pro-inflammatory effects of Vit D deficiency and insufficiency in new-onset type 2 diabetes mellitus and prediabetes.
2023-01-01T00:00:00ZThe Vital Role of Diabetes Nurse Educators in Smoking Cessation: A Case Study from TürkiyeÖzcan, ŞeydaÇarkoğlu, AslıNichter, MimiNichter, MarkAydın, Nuranhttps://hdl.handle.net/20.500.12900/3222024-02-29T12:10:27Z2023-01-01T00:00:00ZThe Vital Role of Diabetes Nurse Educators in Smoking Cessation: A Case Study from Türkiye
Özcan, Şeyda; Çarkoğlu, Aslı; Nichter, Mimi; Nichter, Mark; Aydın, Nuran
This paper discusses the development and implementation of a smoking cessation training program for
diabetes nurse educators. People with diabetes who smoke have a significantly higher risk of morbidity
and mortality. Smoking greatly increases diabetes complications. Surveys were conducted to ascertain how
frequently nurses counseled patients to quit and their interest in cessation training. Observations of nursepatient interactions and interviews with diabetes nurses facilitated the development of a culturally sensitive cessation training program. Survey results revealed that diabetes nurse educators recognized the need
for training in smoking cessation, as many patients with diabetes do not consider smoking to be harmful for their health. A two-day workshop was developed for nurses on the specific harms of smoking for
diabetes patients, including hands-on training in cessation counseling and motivational interviewing. Two
months after training, nurses reported that the skills they acquired gave them confidence to counsel patients
but identified four challenges to conducting cessation in their clinical settings. Diabetes nurse educators
can play a pivotal role in delivering cessation. Training and overcoming challenges to implementation are
urgently needed in the time of coronavirus disease 2019 given the dual risks of diabetes and smoking for
severe complications.
2023-01-01T00:00:00ZIn vitro evaluation of the cytotoxic effects of alkasite restorative material on human dental pulp stem cellsElgun, TugbaCapan, Belen SirinogluDuman, CananOrdueri, Nazli Ece Gungorhttps://hdl.handle.net/20.500.12900/3202024-02-29T12:10:10Z2023-01-01T00:00:00ZIn vitro evaluation of the cytotoxic effects of alkasite restorative material on human dental pulp stem cells
Elgun, Tugba; Capan, Belen Sirinoglu; Duman, Canan; Ordueri, Nazli Ece Gungor
Aim: The clinical suitability of restorative dental materials is determined by evaluating their biocompatibility, and physical and chemical properties. The present
study examined the cytotoxic effects of three different dental restorative materials on human dental pulp stem cells (DPSCs).
Material and Methods: In this study, composite, high-viscosity glass ionomer cement (HVGIC), and an alkasite were used. In total, 12 samples of each material
were prepared for cytotoxicity assays. Cytotoxic effects were determined by considering biomaterial releases. Cell viability and proliferation were observed and
analyzed at intervals of 24 and 72 hours using both the methyl-thiazole-diphenyl-tetrazolium (MTT) and xCELLigence cytotoxicity assays. Data were calculated
using the RTCA-DP integrated software of the xCELLigence system and the GraphPad Prism 9.1.1 program. Data from the proliferation experiments were
statistically evaluated using the Two-way ANOVA test.
Results: Alkasite exhibited the highest cytotoxicity, whereas HVGIC and composite did not exhibit any significant difference compared with the control. There
was no difference between the two time points in the cytotoxicity of composite and alkasite in the MTT assay. However, the cytotoxicity of HVGIC was higher
at 72-hours than at 24-hours. Similar results were obtained with both assays. Although alkasite exhibited higher cytotoxicity than composite and HVGIC, all
materials exerted slightly cytotoxic effects (60%–90% cell viability) on DPSCs.
Discussion: Considering its aesthetic, and mechanical properties, alkasite can be clinically preferred instead of other materials in cavities that are not close
to the dental pulp.
2023-01-01T00:00:00ZPrediction of Preterm Delivery Using Serum Ischemia Modified Albumin, Biglycan, and Decorin Levels in Women with Threatened Preterm LaborBıyık, İsmailSoysal, Cenkİnce, Özlem Ulaş OnurDurmuş, SinemÖztaş, EfserKeskin, NadiIşıklar, Özben ÖzdenKaraağaç, Oğuz HanGelişgen, RemiseUzun, Hafizehttps://hdl.handle.net/20.500.12900/3192024-03-07T06:38:26Z2023-01-01T00:00:00ZPrediction of Preterm Delivery Using Serum Ischemia Modified Albumin, Biglycan, and Decorin Levels in Women with Threatened Preterm Labor
Bıyık, İsmail; Soysal, Cenk; İnce, Özlem Ulaş Onur; Durmuş, Sinem; Öztaş, Efser; Keskin, Nadi; Işıklar, Özben Özden; Karaağaç, Oğuz Han; Gelişgen, Remise; Uzun, Hafize
Objective The serum ischemia modified albumin (IMA), biglycan, and decorin levels of pregnant women who were hospitalized for threatened preterm labor were measured.Methods Fifty-one consecutive pregnant women with a single pregnancy between the 24( th) and 36 (th) weeks with a diagnosis of threatened preterm labor were included in the present prospective cohort study.Results As a result of multivariate logistic regression analysis for predicting preterm delivery within 24 hours, 48 hours, 7 days, 14 days, <= 35 gestational weeks, and <= 37 gestational weeks after admission, area under the curve (AUC) (95% confidence interval [CI[) values were 0.95 (0.89-1.00), 0.93 (0.86-0.99), 0.91 (0.83-0.98), 0.92 (0.85-0.99), 0.82 (0.69-0.96), and 0.89 (0.80-0.98), respectively. In the present study, IMA and biglycan levels were found to be higher and decorin levels lower in women admitted to the hospital with threatened preterm labor and who gave preterm birth within 48 hours compared with those who gave birth after 48 hours.Conclusion In pregnant women admitted to the hospital with threatened preterm labor, the prediction preterm delivery of the combined model created by adding IMA, decorin, and biglycan in addition to the TVS CL measurement was higher than the TVS CL measurement alone.
2023-01-01T00:00:00Z